Phenotypes Associated with This Genotype

Genotype
MGI:7834440

• Allelic Composition: Tg(MMTV-PyVT)634Mul/0
• Genetic Background: B6.FVB-Tg(MMTV-PyVT)634Mul

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:350496 )

• tumors show glandular differentiation and moderated proliferation and tumors show loss of estrogen receptor and progesterone receptor expression and increased HER2 expression following tumor progression

• mice show extensive hyperplasia and multiple tumor foci as early as 4 weeks

increased mammary adenocarcinoma incidence ( J:350496 )

• in late stage of carcinoma, estrogen receptor (ER)-negative cells account for >90% of the tumor volume with scattered clusters of ER+ cells in a small area in 80% of mice while in the other 20% of mice, the amount of ER+ cells in tumors is about 40-50%, suggesting that these tumor cells have not progressed the malignant stage

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:350496 )

• tumors show glandular differentiation and moderated proliferation and tumors show loss of estrogen receptor and progesterone receptor expression and increased HER2 expression following tumor progression

• mice show extensive hyperplasia and multiple tumor foci as early as 4 weeks

increased mammary adenocarcinoma incidence ( J:350496 )

• in late stage of carcinoma, estrogen receptor (ER)-negative cells account for >90% of the tumor volume with scattered clusters of ER+ cells in a small area in 80% of mice while in the other 20% of mice, the amount of ER+ cells in tumors is about 40-50%, suggesting that these tumor cells have not progressed the malignant stage

integument

increased mammary gland tumor incidence ( J:350496 )

• tumors show glandular differentiation and moderated proliferation and tumors show loss of estrogen receptor and progesterone receptor expression and increased HER2 expression following tumor progression

• mice show extensive hyperplasia and multiple tumor foci as early as 4 weeks

increased mammary adenocarcinoma incidence ( J:350496 )

• in late stage of carcinoma, estrogen receptor (ER)-negative cells account for >90% of the tumor volume with scattered clusters of ER+ cells in a small area in 80% of mice while in the other 20% of mice, the amount of ER+ cells in tumors is about 40-50%, suggesting that these tumor cells have not progressed the malignant stage

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:350496