Phenotypes Associated with This Genotype

Genotype
MGI:7865382

• Allelic Composition: Rnf111^em1Fzh/Rnf111⁺
• Genetic Background: C57BL/6J-Rnf111^em1Fzh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

decreased oocyte number ( J:361059 )

♀ • the initial ovarian reserve in resting primordial follicles in P1 mice is decreased

decreased primordial ovarian follicle number ( J:361059 )

♀ • the number of primordial follicles is decreased starting at 2 months of age

♀ • however, the number of growing follicles (primary and secondary follicles) is not affected and follicles are normal at all stages, from primordial to antral follicles

reduced female fertility ( J:361059 )

♀ • females exhibit impaired fertility, producing fewer pups during the mating period, with an average of 28.9 pups compared to 38 pups in wild-type females

♀ • however, age at first birth and litter intervals are similar to wild-type

decreased litter size ( J:361059 )

♀ • number of pups per litter is decreased, with an average of 6 pups compared to 7.1 pups in wild-type females

endocrine/exocrine glands

decreased primordial ovarian follicle number ( J:361059 )

♀ • the number of primordial follicles is decreased starting at 2 months of age

♀ • however, the number of growing follicles (primary and secondary follicles) is not affected and follicles are normal at all stages, from primordial to antral follicles

cellular

decreased oocyte number ( J:361059 )

♀ • the initial ovarian reserve in resting primordial follicles in P1 mice is decreased

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
primary ovarian insufficiency		DOID:5426	OMIM:PS311360	J:361059