Analysis Tools
renal/urinary system
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• mice exhibit proteinuria with age
• however, urine osmolarity levels and overall renal ER stress levels are unaffected
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• more advanced fibrosis is accompanied by extensive inflammation, with T cell infiltration, increased cytokines such as IL-6 and IFN-gamma in the kidney cortex, and increased F4/80 macrophage marker in the glomeruli
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• young mice show a tendency for increased expression of the tubular injury marker lipocalin 2 and slight changes in ER stress markers, suggesting a possible sensitivity to tubular injury
• mice exhibit exacerbation of age-related kidney injury, showing greater glomerular, tubular, and interstitial injuries and increased cytoplasmic vacuolation at 16 months of age compared to wild-type mice
• however, mice show normal kidney development and normal kidney morphology and histology at young ages
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• mice exhibit greater glomerulosclerosis with age than in wild-type mice
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• mice exhibit increased renal fibrosis with age, with a 2-fold increase in collagen deposits in the kidney cortex and medulla interstitium at 16 months of age
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• mice at 14, but not 10, months of age exhibit higher glomerular filtration rates
• however, no changes in urinary volume excreted over 24 hours or in water intake are seen at 10 or 14 months of age
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immune system
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• more advanced fibrosis is accompanied by extensive inflammation, with T cell infiltration, increased cytokines such as IL-6 and IFN-gamma in the kidney cortex, and increased F4/80 macrophage marker in the glomeruli
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homeostasis/metabolism
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• mice exhibit proteinuria with age
• however, urine osmolarity levels and overall renal ER stress levels are unaffected
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| chronic kidney disease | DOID:784 | J:361886 | ||
