Phenotypes Associated with This Genotype

Genotype
MGI:7868165

hm1

• Allelic Composition: Tmem151b^nmf389/Tmem151b^nmf389
• Genetic Background: B6N.B6J-Tmem151b^nmf389/FrkJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

seizures ( J:362012 )

• although homozygotes are not significantly sensitive to kainic acid induced seizures or pentylenetetrazole-induced seizures, they have a reduced threshold for electrically-induced seizures and spontaneous seizures

abnormal seizure response to electrical stimulation ( J:362012 )

increased kindling response ( J:362012 )

• From assessments at 6 to 8 weeks of age, females have a mean seizure threshold of 30.31 + 1.73 iRMS compared with 43.16 + 2.21 iRMS for C57BL/6NJ wildtype controls; males have a mean seizure threshold of 34.64 + 0.6 iRMS compared with 47.38 iRMS for C57BL/6NJ wildtype controls.

maximal tonic hindlimb extension seizures ( J:362012 )

• There is a bypass of the minimal seizure endpoint.

tonic-clonic seizures ( J:362012 )

• spontaneous seizures are observed in older mice

nervous system

seizures ( J:362012 )

• although homozygotes are not significantly sensitive to kainic acid induced seizures or pentylenetetrazole-induced seizures, they have a reduced threshold for electrically-induced seizures and spontaneous seizures

abnormal seizure response to electrical stimulation ( J:362012 )

increased kindling response ( J:362012 )

• From assessments at 6 to 8 weeks of age, females have a mean seizure threshold of 30.31 + 1.73 iRMS compared with 43.16 + 2.21 iRMS for C57BL/6NJ wildtype controls; males have a mean seizure threshold of 34.64 + 0.6 iRMS compared with 47.38 iRMS for C57BL/6NJ wildtype controls.

maximal tonic hindlimb extension seizures ( J:362012 )

• There is a bypass of the minimal seizure endpoint.

tonic-clonic seizures ( J:362012 )

• spontaneous seizures are observed in older mice

abnormal hippocampus CA1 region morphology ( J:362012 )

• Histology at 6 weeks of age shows fewer dendritic processes in the area between the CA pyramidal cells and the granule cells of the dentate gyrus, with a longer distance from the cell body to the first dendritic branch