Phenotypes Associated with This Genotype

Genotype
MGI:7868199

hm2

• Allelic Composition: Tmem151b^nmf389/Tmem151b^nmf389
• Genetic Background: C57BL/6J-Tmem151b^nmf389/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

seizures ( J:362012 )

abnormal seizure response to electrical stimulation ( J:362012 )

increased kindling response ( J:362012 )

• From assessments at 6 to 8 weeks of age, homozygous females have a mean seizure threshold of 35.34 + 2.05 iRMS compared with 41.92 +3.39 iRMS for C57BL/6J wildtype controls; homozygous males have a mean seizure threshold of 41.11 + 2.09 iRMS compared with 47.86 +3.60 iRMS for C57BL/6J wildtype controls.

maximal tonic hindlimb extension seizures ( J:362012 )

• some fatal

tonic-clonic seizures ( J:362012 )

• latency to the first spontaneous seizure ranges from 3 months to a year

nervous system

seizures ( J:362012 )

abnormal seizure response to electrical stimulation ( J:362012 )

increased kindling response ( J:362012 )

• From assessments at 6 to 8 weeks of age, homozygous females have a mean seizure threshold of 35.34 + 2.05 iRMS compared with 41.92 +3.39 iRMS for C57BL/6J wildtype controls; homozygous males have a mean seizure threshold of 41.11 + 2.09 iRMS compared with 47.86 +3.60 iRMS for C57BL/6J wildtype controls.

maximal tonic hindlimb extension seizures ( J:362012 )

• some fatal

tonic-clonic seizures ( J:362012 )

• latency to the first spontaneous seizure ranges from 3 months to a year