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Phenotypes Associated with This Genotype
Genotype
MGI:7868211
cx4
Allelic
Composition		 Tmem151btm1b(KOMP)Wtsi/Tmem151bnmf389
Genetic
Background		 B6N.Cg-Tmem151btm1b(KOMP)Wtsi/Tmem151bnmf389/Frk
Cell Lines EPD0479_2_H11
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmem151bnmf389 mutation (0 available); any Tmem151b mutation (19 available)
Tmem151btm1b(KOMP)Wtsi mutation (1 available); any Tmem151b mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
increased kindling response ( J:362012 )
• From assessments at 6 to 8 weeks of age, compound heterozygous females have a mean seizure threshold of 29.50 + 1.08 iRMS and compound heterozygous males have a mean seizure threshold of 32.01 + 1.62 iRMS, each comparable with homozygous mutants and lower than single heterozygous mutants.

nervous system
increased kindling response ( J:362012 )
• From assessments at 6 to 8 weeks of age, compound heterozygous females have a mean seizure threshold of 29.50 + 1.08 iRMS and compound heterozygous males have a mean seizure threshold of 32.01 + 1.62 iRMS, each comparable with homozygous mutants and lower than single heterozygous mutants.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory