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Phenotypes Associated with This Genotype
Genotype
MGI:8161062
Allelic
Composition
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/?
Genetic
Background
B6.Cg-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/Mmjax
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice exhibit reduced spontaneous alternation in the Y-maze
• mice administered an anti-FAM19A5 antibody intravenously at 8 months of age show increased spontaneous alternation and thus improved performance in the Y-maze test
• mice do not exhibit a preference for the novel object in the novel object recognition test
• mice treated with an anti-FAM195A antibody at 8 months of age show enhanced exploration of a novel object in the novel object recognition test

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Alzheimer's disease DOID:10652 J:360724


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory