Phenotypes Associated with This Genotype

Genotype
MGI:8166400

• Allelic Composition: Dp(11Arf2-Kansl1)9Yah/0
• Genetic Background: involves: 129S1/Sv * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased total body fat amount ( J:244312 )

• mice exhibit lower adiposity levels at 20 weeks of age

behavior/neurological

behavior/neurological phenotype ( J:244312 )

N • mice show no differences in the elevated plus maze, in motor coordination and learning on the rotarod, in the novel object recognition test or in muscular strength on the grip test

enhanced contextual conditioning behavior ( J:244312 )

• in the fear conditioning test, mice exhibit a higher level of freezing with significant differences in the last 2 minutes of test in the context session

enhanced cued conditioning behavior ( J:244312 )

• during the presentation of the conditioning cue of the fear conditioning test, mice show higher levels of freezing during the second 2-minute long cue

slow extinction of fear memory ( J:244312 )

• mice show higher levels of freezing in a fear conditioning/extinction protocol with reinforced conditioned stimuli suggesting that fear trace persists

growth/size/body

decreased body weight ( J:244312 )

• at 20 weeks of age

decreased body length ( J:244312 )

• at 20 weeks of age

nervous system

abnormal brain morphology ( J:244312 )

• reduction in brain volume, with reductions in hippocampus, amygdala, nucleus accumbens, cingulate complex, entorhinal cortex, frontal region, and perirhinal cortex volume

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chromosome 17q21.31 duplication syndrome		DOID:0060434	OMIM:613533	J:244312