Phenotypes Associated with This Genotype

Genotype
MGI:8166401

• Allelic Composition: Kansl1^{tm1b(EUCOMM)Hmgu}/Kansl1⁺
• Genetic Background: involves: C57BL/6N
• Cell Lines: HEPD0766_8_G02

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased total body fat amount ( J:244312 )

• lower adiposity level at 20 weeks of age

behavior/neurological

behavior/neurological phenotype ( J:244312 )

N • no differences are seen in the three-chamber sociability test and in the social interaction test

impaired contextual conditioning behavior ( J:244312 )

• in the fear conditioning test, no differences in baseline or post-shock freezing levels are seen in the conditioning session but mice show lower incidence of freezing in the context session

impaired cued conditioning behavior ( J:244312 )

• in the cue session of the fear conditioning test, mice show decreased freezing level during the second 2-minute cue period

abnormal motor learning ( J:244312 )

• during the learning phase of the rotarod test, mice show higher levels of motor coordination and learning

impaired long-term object recognition memory ( J:244312 )

• in the novel object recognition task with a retention delay of 3 hours, no difference is seen in the acquisition session but mice show a memory impairment during the choice session

enhanced coordination ( J:244312 )

• during the learning phase of the rotarod test, mice show higher levels of motor coordination and learning

• during the test phase of the rotarod test, mice show improvements for speed higher than 10 rpm

abnormal locomotor circadian rhythm ( J:244312 )

• baseline locomotor activity is reduced during the dark phase and the light phase of the circadian activity test

• however, mice exhibit normal patterns of activity in the open field

increased vertical activity ( J:244312 )

• in the novel open field arena, mice show increased rearing behavior

• in odorless home-cages, mice show more intensive rearing behavior

decreased stereotypic behavior ( J:244312 )

• mice show decreased digging behavior in odorless home-cages

growth/size/body

decreased body size ( J:244312 )

• at 20 weeks of age

decreased body weight ( J:244312 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Koolen de Vries syndrome		DOID:0050880	OMIM:610443	J:244312