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Gene Expression Data
Assay Details
Assay
Reference: J:33591 Bellusci S, et al., Evidence from normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesis. Development. 1996 Jun;122(6):1693-702
Assay type: RNA in situ
MGI Accession ID: MGI:1276086
Gene symbol: Bmp4
Gene name: bone morphogenetic protein 4
Probe: Bmp4 cDNA7
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen 1D: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: lung epithelium Strong Regionally restricted 1D Expression is highest in terminal buds.
TS19: main bronchus Weak 1D Expression is weak in the proximal airways.
TS19: trachea Weak 1D Expression is weak in the proximal airways.
TS19: lung mesenchyme Strong Regionally restricted 1D Expression is limited to mesenchyme adjacent to the most distal epithelium.
Specimen 1E & F: embryonic day 11.5 (more )
Note: Fig. 1F is a higher magnification of 1E.
Structure Level Pattern Image Note
TS19: lung epithelium Strong Regionally restricted 1E , 1F Expression is highest in terminal buds.
TS19: lung mesenchyme Strong Regionally restricted 1E , 1F Expression is limited to mesenchyme adjacent to the most distal epithelium.
Specimen not shown: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: lung epithelium Strong Regionally restricted Expression is highest in terminal buds.
TS20: lung mesenchyme Strong Regionally restricted Expression is limited to mesenchyme adjacent to the most distal epithelium.
Specimen 3A: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: lung epithelium Strong Regionally restricted 3A Expression is in localized regions of the distal epithelium presumably corresponding to the distal tips.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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06/12/2024
MGI 6.13 		The Jackson Laboratory