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Gene Expression Data
Assay Details
Assay
Reference: J:50582 Roebroek AJ, et al., Failure of ventral closure and axial rotation in embryos lacking the proprotein convertase Furin. Development. 1998 Dec;125(24):4863-76
Assay type: RNA in situ
MGI Accession ID: MGI:1331350
Gene symbol: Shh
Gene name: sonic hedgehog
Probe: Shh cDNA2
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 5A: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: notochord Present 5A
TS15: neural tube Present 5A
TS15: gut Present 5A
Specimen 5B: embryonic day 9.5; Furintm1Ajmr/Furintm1Ajmr (more )
Structure Level Pattern Image Note
TS15: notochord Present 5B
TS15: neural tube Present 5B
TS15: gut Present 5B No gut tube has formed in mutant, and Shh-expressing cells are at the ventral surface on each side of embryo.
Specimen 6A: embryonic day 9.5 (more )
Note: Sections were taken from whole mounts shown in Fig. 5.
Structure Level Pattern Image Note
TS15: foregut Present Regionally restricted 6A
TS15: notochord Present Uniform 6A
TS15: neural tube floor plate Present Uniform 6A
Specimen 6B: embryonic day 9.5; Furintm1Ajmr/Furintm1Ajmr (more )
Note: Sections were taken from whole mounts shown in Fig. 5.
Structure Level Pattern Image Note
TS15: foregut Present Regionally restricted 6B Shh-positive cells are ectopically situated.
TS15: notochord Present Uniform 6B
TS15: neural tube floor plate Present Uniform 6B
Specimen 6C: embryonic day 9.5; Furintm1Ajmr/Furintm1Ajmr (more )
Note: Sections were taken from whole mounts shown in Fig. 5.
Structure Level Pattern Image Note
TS15: foregut Present Regionally restricted 6C Shh is not detected at more caudal levels of the midgut in mutants, although it is present elsewhere.
TS15: notochord Present Uniform 6C
Specimen 6D: embryonic day 9.5; Furintm1Ajmr/Furintm1Ajmr (more )
Note: Sections were taken from whole mounts shown in Fig. 5.
Structure Level Pattern Image Note
TS15: midgut Present Regionally restricted 6D
TS15: notochord Present Uniform 6D
Specimen 6E: embryonic day 9.5; Furintm1Ajmr/Furintm1Ajmr (more )
Note: Sections were taken from whole mounts shown in Fig. 5.
Structure Level Pattern Image Note
TS15: hindgut Present Regionally restricted 6E
TS15: notochord Present Uniform 6E
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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06/12/2024
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