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Gene Expression Data
Assay Details
Assay
Reference: J:93183 Ruest LB, et al., Endothelin-A receptor-dependent and -independent signaling pathways in establishing mandibular identity. Development. 2004 Sep;131(18):4413-23
Assay type: RNA in situ
MGI Accession ID: MGI:3510694
Gene symbol: Hand2
Gene name: heart and neural crest derivatives expressed 2
Probe: dhand probe16
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen HAND2 Ednra +/+: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: 1st branchial arch mandibular component Present 2Q
Specimen HAND2 Ednra -/-: embryonic day 10.5; Ednratm1Ywa/Ednratm1Ywa (more )
Structure Level Pattern Image Note
TS17: 1st branchial arch mandibular component Absent 2R
Specimen HAND2 Gata3 +/+: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: 1st branchial arch mandibular component Present 4C , 4A
TS17: 2nd branchial arch Present 4C , 4A
Specimen HAND2 Gata3 -/-: embryonic day 10.5; Gata3tm1Jeng/Gata3tm1Jeng (more )
Structure Level Pattern Image Note
TS17: 1st branchial arch mandibular component Present Regionally restricted 4B , 4D Expression is confined to the rostral half of each arch.
TS17: 2nd branchial arch Present Regionally restricted 4B , 4D Expression is confined to the rostral half of each arch.
Specimen HAND2 Dlx5/6 +/+: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS18: 1st branchial arch mandibular component Present 3I , 3K
TS18: 2nd branchial arch Present 3I , 3K
Specimen HAND2 Dlx5/6 -/-: embryonic day 10.5; Dlx5/Dlx6tm1Levi/Dlx5/Dlx6tm1Levi, Dlx5/Dlx6tm1Levi/Dlx5/Dlx6tm1Levi (more )
Note: This embryo was a single homozygote. However, since this allele affects two genes, the MGI database schema requires that we need to enter an allele pair per affected gene (thus resulting in the animal looking like a double homozygote).
Structure Level Pattern Image Note
TS17: 1st branchial arch mandibular component Weak 3L , 3J
TS17: 2nd branchial arch Absent 3J , 3L
Specimen 5I: embryonic day 16.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Tg(Hand2-cre)7-1Clou/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS24: lower jaw incisor dental papilla Present Non-Uniform 5I Expression is present in the dental pulp. The highest expression is in the odontoblast layer, pictured in the inset.
TS24: lower jaw incisor dental lamina Absent 5I
TS24: mandible Present 5I
Specimen Not shown: embryonic day 16.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Tg(Hand2-cre)7-1Clou/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS24: upper jaw incisor Absent
Specimen 5J: embryonic day 16.5; Ednratm1Ywa/Ednratm1Ywa, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Tg(Hand2-cre)7-1Clou/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS24: lower jaw incisor dental papilla Present Non-Uniform 5J Expression is present in the dental pulp. The highest expression is in the odontoblast layer, pictured in the inset.
TS24: lower jaw incisor dental lamina Absent 5J
TS24: vibrissa Present Regionally restricted 5J Expression is present in the shaft.
Specimen Not shown: embryonic day 16.5; Ednratm1Ywa/Ednratm1Ywa, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Tg(Hand2-cre)7-1Clou/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS24: mandible Present Expression is present in the residual bone and cartilage.
TS24: upper jaw incisor Absent
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory