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Gene Expression Data
Assay Details
Assay
Reference: J:67054 Laurikkala J, et al., TNF signaling via the ligand-receptor pair ectodysplasin and edar controls the function of epithelial signaling centers and is regulated by Wnt and activin during tooth organogenesis. Dev Biol. 2001 Jan 15;229(2):443-55
Assay type: RNA in situ
MGI Accession ID: MGI:3513989
Gene symbol: Eda
Gene name: ectodysplasin-A
Probe: Ta probe
Probe preparation: labelled with S35 RNA
Results
Specimen 1A: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: 1st branchial arch mandibular component Present 1A Prior to morphological tooth formation, expression throughout the simple oral epithelium covering the mandibular arch.
TS17: oral epithelium Present 1A Prior to morphological tooth formation, expression throughout the simple oral epithelium covering the mandibular arch.

Specimen 1C: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: mandibular process Present Regionally restricted 1C During initiation of tooth development, expression is reduced in the thickened presumptive dental epithelium.
TS19: oral epithelium Present 1C Authors state that expression continues in oral epithelium

Specimen 1E: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: mandibular process Absent 1E During early bud stage, expression is absent in dental epithelium starting to bud.
TS20: oral epithelium Present 1E Authors state that expression continues in oral epithelium

Specimen 1G: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: tooth epithelium Strong Regionally restricted 1G At bud stage, intense expression in basal cells of the fully developed bud (outer epithelium of tooth germ), except for the forming signaling center at the tip, corresponding to the enamel knot.
TS21: enamel knot Absent 1G
TS21: oral epithelium Present 1G

Specimen 1I: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: outer enamel epithelium Strong Regionally restricted 1I At cap stage, intense expression in the outer enamel epithelium.
TS22: inner enamel epithelium Absent 1I
TS22: oral epithelium Present 1I

Specimen 1K: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: outer enamel epithelium Present 1K Persistent expression in outer enamel epithelium.

Specimen 1M: postnatal newborn (more )
Structure Level Pattern Image Note
TS27: outer enamel epithelium Present 1M Persistent expression in outer enamel epithelium.

Specimen 5A: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: oral epithelium Present 5A
TS19: mandible primordium Present 5A Expression in presumptive dental epithelium in mandible and maxilla.
TS19: maxilla primordium Present 5A Expression in presumptive dental epithelium in mandible and maxilla.

Specimen 5B: embryonic day 11.5; Lef1tm1Rug/Lef1tm1Rug (more )
Structure Level Pattern Image Note
TS19: mandible primordium Absent 5B No expression in ectoderm covering mandibular and maxillary processes.
TS19: maxilla primordium Absent 5B No expression in ectoderm covering mandibular and maxillary processes.

Specimen 5C: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: tooth epithelium Present Regionally restricted 5C Expression in outer epithelium of tooth bud.

Specimen 5D: embryonic day 13.5; Lef1tm1Rug/Lef1tm1Rug (more )
Structure Level Pattern Image Note
TS21: tooth epithelium Weak Regionally restricted 5D Expression significantly downregulated in dental epithelium and oral ectoderm flanking the tooth buds. No expression on lingual aspect of tooth buds; variable weak expression on buccal side.

Specimen 5E: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: outer enamel epithelium Strong 5E Intesnse expression in outer enamel epithelium.

Specimen 5F: embryonic day 14.5; Lef1tm1Rug/Lef1tm1Rug (more )
Structure Level Pattern Image Note
TS22: tooth epithelium Weak Regionally restricted 5F Expression on buccal but not lingual aspects of tooth germs.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
09/17/2024
MGI 6.24
The Jackson Laboratory