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Gene Expression Data
Assay Details
Assay
Reference: J:98919 Cobb J, et al., Comparative analysis of genes downstream of the Hoxd cluster in developing digits and external genitalia. Development. 2005 Jul;132(13):3055-67
Assay type: RNA in situ
MGI Accession ID: MGI:3689897
Gene symbol: Epha3
Gene name: Eph receptor A3
Probe: Epha3 cDNA1
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 5B Wild type left: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: forelimb Present 5B Epha3 Wild type left
Specimen 5B HoxD Del1-13 left: embryonic day 12.5; Hoxdtm21(Hoxd11)Ddu/Hoxdtm21(Hoxd11)Ddu (more )
Structure Level Pattern Image Note
TS20: forelimb Present Regionally restricted 5B Epha3 HoxD Del1-13 left Expression levels were increased posteriorly and distally.
Specimen 5B Wild type right: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: genital tubercle Present 5B Epha3 Wild type right
Specimen 5B HoxD Del1-13 right: embryonic day 13.5; Hoxdtm21(Hoxd11)Ddu/Hoxdtm21(Hoxd11)Ddu (more )
Structure Level Pattern Image Note
TS21: genital tubercle Present 5B Epha3 HoxD Del1-13 right The expression domain was slightly broader in the mutant genital bud.
Specimen 6B Wild type: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: handplate Present Regionally restricted 6B Wild type Expression was detected in the most anterior part of the handplate.
Specimen 6B HoxD Del1-10/Del1-10: embryonic day 11.5; Del(2Hoxd1-Hoxd10)26Ddu/Del(2Hoxd1-Hoxd10)26Ddu (more )
Structure Level Pattern Image Note
TS19: handplate Absent 6B HoxD Del1-10/Del1-10 Expression was lost in the most anterior part of the handplate where the mutant Hoxd13 expression is gained.
Specimen 7A: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: forelimb Present 7A
Specimen 7B: embryonic day 12.5; Hoxdtm21(Hoxd11)Ddu/Hoxd+, Hoxa13tm2Ipc/Hoxa13+ (more )
Structure Level Pattern Image Note
TS20: forelimb Present 7B Expression is moderately gained compared to wild type.
Specimen 7C: embryonic day 12.5; Hoxdtm21(Hoxd11)Ddu/Hoxdtm21(Hoxd11)Ddu, Hoxa13tm2Ipc/Hoxa13+ (more )
Structure Level Pattern Image Note
TS20: forelimb Present 7C The expression domain is much larger distally and posteriorly compared to the Hoxd mutant only (compare with Fig. 5B).
Specimen 7D: embryonic day 12.5; Hoxdtm21(Hoxd11)Ddu/Hoxdtm21(Hoxd11)Ddu, Hoxa13tm2Ipc/Hoxa13tm2Ipc (more )
Structure Level Pattern Image Note
TS20: forelimb Present 7D The expression domain was further gained to the posterior of the forelimb bud compared to Fig. 7C.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/17/2024
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