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Gene Expression Data
Assay Details
Assay
Reference: J:33496 Akhurst RJ, et al., TGF beta in murine morphogenetic processes: the early embryo and cardiogenesis. Development. 1990 Apr;108(4):645-56
Assay type: RNA in situ
MGI Accession ID: MGI:3839455
Gene symbol: Tgfb1
Gene name: transforming growth factor, beta 1
Probe: Tgfb1 probe2
Probe preparation: Antisense labelled with S35 RNA
Visualized with: Autoradiography
Results
Specimen 1A,B: embryonic day 7.5 (more )
Structure Level Pattern Image Note
TS28: decidua Strong Regionally restricted 1A , 1B Authors report abundant expression in the maternal deciduum.
TS28: decidua capsularis Present Regionally restricted 1A , 1B Gradient across the decidua capsularis, with highest expression near the uterine wall.

Specimen 1D,E: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS28: decidua basalis Present Regionally restricted 1D , 1E Expression in the decidua basalis; most intense in the cells lining lacunae.

Specimen 7.0 dpc: embryonic day 7.0 (more )
Structure Level Pattern Image Note
TS10: yolk sac Present Regionally restricted Expression in the blood islands of the yolk sac.
TS10: allantois Strong

Specimen 1G,H: embryonic day 7.5 (more )
Structure Level Pattern Image Note
TS11: yolk sac Present Regionally restricted 1G , 1H Expression evely distributed over all cells of the blood island.

Specimen 8.5 dpc: embryonic day 8.5 (more )
Structure Level Pattern Image Note
TS13: allantois Strong

Specimen 1I: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: yolk sac Strong Regionally restricted 1I Intense expression in clusters of cells in the blood islands.

Specimen 12.5 dpc: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: liver Present Regionally restricted Expression in erythroid progenitors.

Specimen 2A,B: embryonic day 7.5 (more )
Structure Level Pattern Image Note
TS11: embryo mesoderm Present Regionally restricted 2A , 2B Expression in cardiac mesoderm cells within the head region. Authors state that no other ectodermal, endodermal or mesodermal tissues showed expression.

Specimen 2D,E: embryonic day 7.5 (more )
Structure Level Pattern Image Note
TS11: embryo mesoderm Present Regionally restricted 2E , 2D Expression in cardiac mesoderm cells within the head region.

Specimen 3A,B: embryonic day 8.0 (more )
Structure Level Pattern Image Note
TS12: endocardial tube Present 3B , 3A Expression in the endocardium.
TS12: cardiac muscle tissue Absent 3B , 3A No expression in the myocardium.

Specimen 3C,D: embryonic day 8.5 (more )
Structure Level Pattern Image Note
TS13: head mesenchyme Present Regionally restricted 3D , 3C Expression in isolated cells within the head mesenchyme.
TS13: endocardial tube Present Regionally restricted 3D , 3C Expression in endocardial cells.

Specimen 3F,G: embryonic day 8.5 (more )
Structure Level Pattern Image Note
TS13: endocardial tube Strong Regionally restricted 3F , 3G High levels of expression in all endocardial cells.

Specimen 9.5 dpc - embryo: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: embryo Present Regionally restricted Authors report expression in cells immediately adjacent to the neural tube, believed to be capillary endothelial cells undergoing angiogenesis, along the entire axis of the embryo.

Specimen 4A,B: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: arterial system Present Regionally restricted 4A , 4B Authors report expression in endothelial cells of the major blood vessels, including the internal carotid artery, anterior cardinal veins, and caudal arteries and veins.
TS15: venous system Present Regionally restricted 4A , 4B Authors report expression in endothelial cells of the major blood vessels, including the internal carotid artery, anterior cardinal veins, and caudal arteries and veins.
TS15: anterior cardinal vein Present 4A , 4B
TS15: internal carotid artery Present 4A , 4B

Specimen 11.0 dpc: embryonic day 11.0 (more )
Structure Level Pattern Image Note
TS18: arterial system Present Regionally restricted Expression in truncus venosus and hepatocardiac channel; no expression in the internal carotid artery, anterior cardinal veins, and caudal arteries and veins.
TS18: venous system Present Regionally restricted Expression in truncus venosus and hepatocardiac channel; no expression in the internal carotid artery, anterior cardinal veins, and caudal arteries and veins.
TS18: anterior cardinal vein Absent Expression in truncus venosus and hepatocardiac channel; no expression in the internal carotid artery, anterior cardinal veins, and caudal arteries and veins.
TS18: internal carotid artery Absent Expression in truncus venosus and hepatocardiac channel; no expression in the internal carotid artery, anterior cardinal veins, and caudal arteries and veins.

Specimen 5A,B: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: outflow tract Strong Regionally restricted 5B , 5A High expression in the outflow tract.
TS15: common atrial chamber endocardial lining Absent 5A , 5B No expression in endocardium overlying the atrial myocardium.

Specimen 5D,E: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: endocardial cushion Strong Regionally restricted 5E , 5D High levels of expression in endothelium overlying the cushion tissue.
TS15: primitive ventricle endocardial lining Absent 5E , 5D No expression in endocardium overlying the ventricular myocardium.

Specimen 5G,H: embryonic day 9.5 (more )
Note: Higher level magnification of section 5D,E.
Structure Level Pattern Image Note
TS15: endocardial cushion Strong Regionally restricted 5H , 5G

Specimen 9.5 dpc - heart: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: heart Strong Regionally restricted High levels of expression in atrioventricular valve region.

Specimen 5J,K: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: heart Present Regionally restricted 5J , 5K

Specimen 5M,N: embryonic day 10.5 (more )
Note: Section showing ventricle and outflow tract.
Structure Level Pattern Image Note
TS17: heart Present Regionally restricted 5N , 5M

Specimen 7A,B: postnatal newborn (more )
Structure Level Pattern Image Note
TS27: atrioventricular valve Absent 7A , 7B Authors report no expression in atrioventricular valves.

Specimen 7D,E: postnatal week 6 (more )
Structure Level Pattern Image Note
TS28: aortic valve Absent 7E , 7D Authors report no expression in the semilunar valve of the aorta.


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory