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Gene Expression Data
Assay Details
Assay
Reference: J:112945 Okubo T, et al., Sox2 is required for development of taste bud sensory cells. Genes Dev. 2006 Oct 1;20(19):2654-9
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:4834765
Gene symbol: Sox2
Gene name: SRY (sex determining region Y)-box 2
Reporter: GFP
Direct Detection
Results
Specimen 1A: embryonic day 12.5; Sox2tm1Lpev/Sox2+ (more )
Structure Level Pattern Image Note
TS20: tongue epithelium Present Regionally restricted 1A Expression was detected in the surface epithelium of the tongue.
Specimen 1B: embryonic day 13.5; Sox2tm1Lpev/Sox2+ (more )
Structure Level Pattern Image Note
TS21: tongue Present Regionally restricted 1B Expression was higher in the developing fungiform papillae compared with the surrounding epithelium.
TS21: tongue epithelium Present 1B
Specimen 1C: embryonic day 13.5; Sox2tm1Lpev/Sox2+ (more )
Structure Level Pattern Image Note
TS21: tongue Present Regionally restricted 1C Expression was detected in columnar placode cells. Expression was higher in the developing fungiform papillae compared with the surrounding epithelium.
TS21: tongue epithelium Present 1C
Specimen 1E: embryonic day 17.5; Sox2tm1Lpev/Sox2+ (more )
Structure Level Pattern Image Note
TS25: circumvallate papillae Present 1E
TS25: foliate papillae Present 1E
TS25: fungiform papillae Present 1E
Specimen 1F: embryonic day 17.5; Sox2tm1Lpev/Sox2+ (more )
Structure Level Pattern Image Note
TS25: secondary palate Present Regionally restricted 1F Expression was detected in palate taste buds.
Specimen 1G: postnatal day 5; Sox2tm1Lpev/Sox2+ (more )
Structure Level Pattern Image Note
TS28: fungiform papillae Present 1G
TS28: soft palate Present 1G
Specimen 1H: postnatal day 5; Sox2tm1Lpev/Sox2+ (more )
Structure Level Pattern Image Note
TS28: taste bud Present Regionally restricted 1H Expression was detected in all differentiated taste bud cells.
TS28: fungiform papillae Present 1H
Specimen 1I: postnatal day 5; Sox2tm1Lpev/Sox2+ (more )
Structure Level Pattern Image Note
TS28: circumvallate papillae Present 1I
TS28: foliate papillae Present 1I
TS28: soft palate Present 1I
Specimen 1J: postnatal day 60; Sox2tm1Lpev/Sox2+ (more )
Structure Level Pattern Image Note
TS28: fungiform papillae Present 1J
TS28: soft palate Present 1J
Specimen 1K: postnatal day 60; Sox2tm1Lpev/Sox2+ (more )
Structure Level Pattern Image Note
TS28: taste bud Present Regionally restricted 1K Expression was detected in all differentiated taste bud cells.
TS28: fungiform papillae Present 1K
Specimen 1L: postnatal day 60; Sox2tm1Lpev/Sox2+ (more )
Structure Level Pattern Image Note
TS28: circumvallate papillae Strong 1L
Specimen S1A: postnatal month 9; Sox2tm1Lpev/Sox2+ (more )
Structure Level Pattern Image Note
TS28: fungiform papillae Present S1A
Specimen S1B: postnatal month 9; Sox2tm1Lpev/Sox2+ (more )
Structure Level Pattern Image Note
TS28: circumvallate papillae Present S1B
TS28: foliate papillae Present S1B
Specimen S2B: embryonic day 14.5; Sox2tm1Lpev/Sox2+ (more )
Structure Level Pattern Image Note
TS22: fungiform papillae Present S2B
Specimen S2C: embryonic day 14.5; Sox2tm1Lpev/Sox2tm3Lpev (more )
Structure Level Pattern Image Note
TS22: fungiform papillae Present S2C
Specimen S2D: embryonic day 16.5; Sox2tm1Lpev/Sox2+ (more )
Structure Level Pattern Image Note
TS24: fungiform papillae Present S2D
TS24: tongue epithelium Present S2D
Specimen S2E: embryonic day 16.5; Sox2tm1Lpev/Sox2tm3Lpev (more )
Structure Level Pattern Image Note
TS24: fungiform papillae Trace S2E Expression was detected in the fungiform papillae, but there were far fewer fungiform papillae in the mutants compared to wild type.
TS24: tongue epithelium Trace S2E Expression was reduced in the tongue epithelium.
Specimen 2A: postnatal day 0; Sox2tm1Lpev/Sox2+ (more )
Structure Level Pattern Image Note
TS27: fungiform papillae Present 2A
Specimen 2B: postnatal day 0; Sox2tm1Lpev/Sox2tm3Lpev (more )
Structure Level Pattern Image Note
TS27: fungiform papillae Absent 2B The mutant tongues had no fungiform papillae.
Specimen S3A: postnatal day 0; Sox2tm1Lpev/Sox2+ (more )
Structure Level Pattern Image Note
TS27: taste bud Present Regionally restricted S3A Expression was detected in the taste bud cells in the palate.
Specimen S3B: postnatal day 0; Sox2tm1Lpev/Sox2tm3Lpev (more )
Structure Level Pattern Image Note
TS27: taste bud Absent S3B There is a deficiency of palate taste buds in the mutant.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/19/2024
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