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Gene Expression Data
Assay Details
Assay
Reference: J:96871 Chi H, et al., Loss of mitogen-activated protein kinase kinase kinase 4 (MEKK4) results in enhanced apoptosis and defective neural tube development. Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3846-51
Assay type: Immunohistochemistry
MGI Accession ID: MGI:4947649
Gene symbol: Map2k4
Gene name: mitogen-activated protein kinase kinase 4
Antibody: Anti-Phospho-MKK4
Detection system: Biotinylated secondary antibody/[Strept]avidin coupled to horseradish peroxidase
Assay notes: The antibody used in this assay recognized the phosphorylated (activated) form of the protein.
Results
Specimen 4A Top MEKK4+/+: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: central nervous system Present Regionally restricted 4A HB Mekk4 +/+ Expression was detected in cells lining the CNS ventricles.
TS15: future hindbrain Present Regionally restricted 4A HB Mekk4 +/+ Expression was detected in the rostral portions of the hindbrain neural folds.
Specimen 4A Top MEKK4-/-: embryonic day 9.5; Map3k4tm1Flv/Map3k4tm1Flv (more )
Structure Level Pattern Image Note
TS15: future hindbrain Weak 4A HB Mekk4 -/- Expression was significantly reduced in the hindbrain neuroepithelium.
Specimen 4A Bottom MEKK4+/+: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: central nervous system Present Regionally restricted 4A FB Mekk4 +/+ Expression was detected in cells lining the CNS ventricles.
TS15: future forebrain Present Regionally restricted 4A FB Mekk4 +/+ Expression was detected in the anterior forebrain neuroepithelium surrounding the lamina terminalis.
Specimen 4A Bottom MEKK4-/-: embryonic day 9.5; Map3k4tm1Flv/Map3k4tm1Flv (more )
Structure Level Pattern Image Note
TS15: future forebrain Weak 4A FB Mekk4 -/- Expression was significantly reduced in the forebrain neuroepithelium.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory