Gene Expression Data
Assay Details
Assay
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Reference:
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J:203658
Yariz KO, et al., Mutations in OTOGL, encoding the inner ear protein otogelin-like, cause moderate sensorineural hearing loss. Am J Hum Genet. 2012 Nov 2;91(5):872-82
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Assay type:
|
Immunohistochemistry
|
MGI Accession ID:
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MGI:5556390
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Gene symbol:
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Otogl
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Gene name:
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otogelin-like
|
|
Results
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Specimen
3A:
embryonic day 17.5
(more )
Note: Triple labeled: red - Otogl; green - Myo7a (assay MGI:5559193); white - Sox2 (assay MGI:5559197).
Specimen
3A:
(close )
Genetic Background:
|
CD-1
|
Age:
|
embryonic day 17.5
|
Sex:
|
Not Specified
|
Type:
|
section
|
Embedding:
|
Cryosection
|
Note:
|
Triple labeled: red - Otogl; green - Myo7a (assay MGI:5559193); white - Sox2 (assay MGI:5559197).
|
Structure |
Level |
Pattern |
Image |
Note |
TS25: cochlea |
Present |
Regionally restricted |
3A
,
3A'
|
Expression is present on the lumen surface of interdental cells close to the Reissner's membrane and the base of tectorial membrane.
|
TS25: cochlear duct |
Present |
Regionally restricted |
3A'
,
3A
|
Expression is present in the spiral prominence.
|
TS25: organ of Corti |
Present |
Non-Uniform |
3A
,
3A'
|
Expression is present in the Claudius cells and weakly in hair cells.
|
Specimen
3C:
postnatal day 0
(more )
Note: Triple labeled: red - Otogl; green - Myo7a (assay MGI:5559193); white - Sox2 (assay MGI:5559197).
Specimen
3C:
(close )
Genetic Background:
|
CD-1
|
Age:
|
postnatal day 0
|
Sex:
|
Not Specified
|
Type:
|
section
|
Embedding:
|
Cryosection
|
Note:
|
Triple labeled: red - Otogl; green - Myo7a (assay MGI:5559193); white - Sox2 (assay MGI:5559197).
|
Structure |
Level |
Pattern |
Image |
Note |
TS27: cochlea |
Present |
Non-Uniform |
3C
,
3C''
,
3C'
|
There is clear staining in the Deiters cells. Expression is also present on the lumen surface of interdental cells close to the Reissner's membrane.
|
TS27: spiral prominence |
Present |
|
3C
,
3C''
,
3C'
|
|
TS27: organ of Corti |
Present |
Non-Uniform |
3C
,
3C''
,
3C'
|
Expression is present in the Claudius cells and in hair cells.
|
TS27: tectorial membrane |
Present |
Non-Uniform |
3C''
,
3C'
,
3C
|
Expression is present at the base.
|
Specimen
3D:
postnatal day 0
(more )
Note: Triple labeled: red - Otogl; green - Myo7a (assay MGI:5559193); white - Sox2 (assay MGI:5559197).
Specimen
3D:
(close )
Genetic Background:
|
CD-1
|
Age:
|
postnatal day 0
|
Sex:
|
Not Specified
|
Type:
|
section
|
Embedding:
|
Cryosection
|
Note:
|
Triple labeled: red - Otogl; green - Myo7a (assay MGI:5559193); white - Sox2 (assay MGI:5559197).
|
Structure |
Level |
Pattern |
Image |
Note |
TS27: saccule |
Present |
Non-Uniform |
3D'
,
3D
|
There is prominent expression in the saccular roof, likely in the otolithic membrane. There is weak expression in the hair cells.
|
Specimen
3F:
postnatal day 6
(more )
Note: Triple labeled: red - Otogl; green - Myo7a (assay MGI:5559193); white - Sox2 (assay MGI:5559197).
Specimen
3F:
(close )
Genetic Background:
|
CD-1
|
Age:
|
postnatal day 6
|
Sex:
|
Not Specified
|
Type:
|
section
|
Embedding:
|
Cryosection
|
Note:
|
Triple labeled: red - Otogl; green - Myo7a (assay MGI:5559193); white - Sox2 (assay MGI:5559197).
|
Structure |
Level |
Pattern |
Image |
Note |
TS28: cochlear duct |
Present |
Regionally restricted |
3F'
,
3F''
,
3F
|
Expression is present in the Deiters cells.
|
TS28: organ of Corti |
Present |
Regionally restricted |
3F''
,
3F'
,
3F
|
Expression is restricted to outer hair cells, Pillar cells and Claudius cells.
|
TS28: tectorial membrane |
Present |
Regionally restricted |
3F''
,
3F'
,
3F
|
Expression is restricted to the base.
|
Specimen
3H:
postnatal day 6
(more )
Note: Triple labeled: red - Otogl; green - Myo7a (assay MGI:5559193); white - Sox2 (assay MGI:5559197).
Specimen
3H:
(close )
Genetic Background:
|
CD-1
|
Age:
|
postnatal day 6
|
Sex:
|
Not Specified
|
Type:
|
section
|
Embedding:
|
Cryosection
|
Note:
|
Triple labeled: red - Otogl; green - Myo7a (assay MGI:5559193); white - Sox2 (assay MGI:5559197).
|
Structure |
Level |
Pattern |
Image |
Note |
TS28: saccule |
Present |
Regionally restricted |
3H'
,
3H
|
There is strong staining in the roof. Expression in the hair cells is still weak.
|
|