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Gene Expression Data
Assay Details
Assay
Reference: J:211312 Woo SH, et al., Piezo2 is required for Merkel-cell mechanotransduction. Nature. 2014 May 29;509(7502):622-6
Assay type: Immunohistochemistry
MGI Accession ID: MGI:5697547
Gene symbol: Piezo2
Gene name: piezo-type mechanosensitive ion channel component 2
Antibody: anti-Piezo2
Detection system: Secondary antibody
Results
Specimen Ext. 1C: postnatal adult; Piezo2tm1.1(cre)Apat/Piezo2tm1.1(cre)Apat (more )
Note: Double labeled: green - Piezo2 protein; red - Piezo2 reporter (assay MGI:5697408).
Structure Level Pattern Image Note
TS28: dorsal root ganglion Present Non-Uniform Extended Data 1C Merge , Extended Data 1C Piezo2 Expression is seen in 45.6% of the neurons; high expression levels are seen in a quarter of those neurons.
Specimen Ext. 1D: postnatal adult (more )
Structure Level Pattern Image Note
TS28: dorsal root ganglion Present Non-Uniform Extended Data 1D Piezo2 , Extended Data 1D Merge Expression is seen in 45.6% of the neurons; high expression levels are seen in a quarter of those neurons.
Specimen Ext. 3C: postnatal newborn (more )
Structure Level Pattern Image Note
TS27: dorsal root ganglion Present Extended Data 3C
Specimen Ext. 3D: postnatal newborn; Piezo2tm2.1Apat/Piezo2tm2.1Apat (more )
Structure Level Pattern Image Note
TS27: dorsal root ganglion Absent Extended Data 3D
Specimen 2D: postnatal; Piezo2tm2.2Apat/Piezo2tm2.2Apat (more )
Note: Whisker pad. Double labeled: green - Piezo2; red - Krt8 (assay MGI:5697549).
Structure Level Pattern Image Note
TS28: face skin Present Single cells 2D Piezo2 , 2D Krt8/Piezo2 Expression is seen in the Merkel cells of the whisker pads.
Specimen 2E: postnatal; Piezo2tm2.2Apat/Piezo2tm2.2Apat, Tg(KRT14-cre)1Amc/0 (more )
Note: Conditional mutant. Whisker pad. Double labeled: green - Piezo2; red - Krt8 (assay MGI:5697549).
Structure Level Pattern Image Note
TS28: face skin Absent 2E Piezo2 , 2E Krt8/Piezo2 In the mutant, expression has been abolished from all epithelial cells, including Merkel cells.
Specimen 2F: postnatal; Piezo2tm2.2Apat/Piezo2tm2.2Apat, Tg(KRT14-cre)1Amc/0 (more )
Note: Conditional mutant. Whisker pad. Triple labeled: green - Piezo2; red - Krt8 (assay MGI:5697549); blue - Nefh (assay MGI:5697548).
Structure Level Pattern Image Note
TS28: face skin Absent 2F Krt8/Piezo2/Nefh , 2F Piezo2 In the mutant, expression has been abolished from all epithelial cells, including Merkel cells.
TS28: peripheral nervous system Present Regionally restricted 2F Piezo2 , 2F Krt8/Piezo2/Nefh Expression is present in the sensory afferents that innervate Merkel cells.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/10/2024
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