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Gene Expression Data
Assay Details
Assay
Reference: J:43263 Oulad-Abdelghani M, et al., Meis2, a novel mouse Pbx-related homeobox gene induced by retinoic acid during differentiation of P19 embryonal carcinoma cells. Dev Dyn. 1997 Oct;210(2):173-83
Assay type: RNA in situ
MGI Accession ID: MGI:5823059
Gene symbol: Meis2
Gene name: Meis homeobox 2
Probe: Meis2b cDNA
Probe preparation: Antisense labelled with S35 RNA
Results
Specimen 7.5 dpc not shown: embryonic day 7.5 (more )
Structure Level Pattern Image Note
TS11: neural ectoderm Present Expression mostly in neural and non-neural ectoderm.
TS11: non-neural ectoderm Present Expression mostly in neural and non-neural ectoderm.

Specimen 5A: embryonic day 8.0 (more )
Structure Level Pattern Image Note
TS12: neural tube Present Widespread 5A Expression distributed throughout the neural tube.
TS12: embryo mesoderm Present Regionally restricted 5A Authors report expression in various mesodermal regions.
TS12: somite Strong 5A Stronger expression in somitic and presomitic mesoderm.
TS12: trunk unsegmented mesenchyme Strong 5A Stronger expression in somitic and presomitic mesoderm.
TS12: lateral plate mesoderm Present 5A

Specimen 5B: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: future midbrain Present Regionally restricted 5B Sharply defined expression domain in midbrain.
TS15: telencephalon Present 5B Clear expression in telencephalic neurectoderm.
TS15: optic stalk Present 5B
TS15: heart Strong Regionally restricted 5B Strong expression in dorsal regions of the heart.
TS15: trunk mesenchyme Strong Regionally restricted 5B Strong expression in trunk mesenchyme at level of forelimb buds.

Specimen 10.5 dpc not shown: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: brain Present Regionally restricted Authors report expression in specific areas of brain.
TS17: hindlimb bud Present Regionally restricted Expression restricted to proximal regions of hindlimb buds.

Specimen 5C: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: telencephalon Present Regionally restricted 5C Expression in telencephalic vesicles and ganglionic eminence.
TS19: diencephalon Present Regionally restricted 5C Expression in part of dorsal thalamus.
TS19: midbrain Present Regionally restricted 5C Expression restricted to tectum and pyramidal tract.
TS19: hindbrain Present Regionally restricted 5C No expression in a region between the pons and rhombic isthmus.
TS19: cranial ganglion Present 5C
TS19: dorsal root ganglion Present 5C
TS19: 1st branchial arch maxillary component Present 5C Authors report discrete expression in maxillary region.
TS19: 1st branchial arch Present Regionally restricted 5C Expression in maxillo-mandibular cleft epithelium.
TS19: fronto-nasal process mesenchyme Absent 5C
TS19: mandibular process mesenchyme Absent 5C
TS19: inner ear epithelium Present 5C
TS19: nasal epithelium Present 5C
TS19: oral epithelium Present 5C
TS19: liver Absent 5C
TS19: myotome Present Regionally restricted 5C Expression persisted in myotomal derivatives.
TS19: sclerotome Absent 5C

Specimen 5D: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: telencephalon Present Regionally restricted 5D Expression in telencephalic vesicles.
TS21: ganglionic eminence Present 5D
TS21: diencephalon Present Regionally restricted 5D Expression in part of dorsal thalamus.
TS21: maxilla Present 5D Expression persisted in derivatives of maxillary process.
TS21: ear epithelium Present 5D
TS21: nasal cavity epithelium Present 5D
TS21: oral epithelium Present 5D
TS21: mandible Absent 5D No expression in distal mesenchyme of tongue, mandible, and nasal regions.
TS21: nasal mesenchyme Absent 5D No expression in distal mesenchyme of tongue, mandible, and nasal regions.
TS21: tongue mesenchyme Absent 5D No expression in distal mesenchyme of tongue, mandible, and nasal regions.
TS21: epidermis Present 5D
TS21: vibrissa follicle Present 5D
TS21: gut mesenchyme Strong 5D
TS21: mesenchyme of metanephros Strong 5D
TS21: stomach mesenchyme Strong 5D
TS21: stomach epithelium Present Regionally restricted 5D Specific expression in some regions of stomach glandular epithelium.
TS21: heart Weak 5D
TS21: lung Weak 5D
TS21: gonad Absent 5D
TS21: liver Absent 5D

Specimen 6A: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: future spinal cord Present Regionally restricted 6A Expression distributed throughout the spinal cord. Stronger expression in ventral horns.
TS15: heart Strong Regionally restricted 6A Strong expression in dorsal regions of the heart.
TS15: trunk mesenchyme Strong Regionally restricted 6A Strong expression in trunk mesenchyme at level of forelimb buds.
TS15: forelimb bud mesenchyme Present Regionally restricted 6A Expression extends in forelimb buds, gradually decreasing towards distal regions.
TS15: gut mesenchyme Present 6A
TS15: gut endoderm Absent 6A

Specimen 6B: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: future spinal cord Present Regionally restricted 6B Expression distributed throughout the spinal cord. Stronger expression in ventral horns.
TS17: heart Strong Regionally restricted 6B Strong expression in dorsal regions of the heart.
TS17: trunk mesenchyme Strong Regionally restricted 6B Strong expression in trunk mesenchyme at level of forelimb buds.
TS17: forelimb bud mesenchyme Present Regionally restricted 6B Expression restricted to proximal regions of forelimb buds.

Specimen 6C: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: future spinal cord Present Regionally restricted 6C Expression in ventral horns.
TS19: neural tube mantle layer Present Regionally restricted 6C Expression in more dorsal regions of mantle layer of spinal cord.
TS19: neural tube floor plate Absent 6C
TS19: dorsal root ganglion Present 6C
TS19: trunk myotome Present 6C Expression persisted in myotomal derivatives.
TS19: trunk sclerotome Absent 6C

Specimen 7A: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: stomach epithelium Present Regionally restricted 7A Specific expression in some regions of stomach glandular epithelium.
TS19: forelimb bud mesenchyme Present Regionally restricted 7A Expression restricted to very proximal limb mesenchyme and to a central cell condensation.
TS19: forelimb bud ectoderm Present Regionally restricted 7A Expression also detected in surface ectoderm of limbs.

Specimen 7B: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: gut mesenchyme Strong 7B
TS21: mesenchyme of metanephros Strong 7B
TS21: stomach mesenchyme Strong 7B
TS21: gut epithelium Absent 7B
TS21: hindlimb Present Regionally restricted 7B Expression throughout developing tissues of proximal limb regions, except for differentiating cartilage and bone.
TS21: hindlimb cartilage condensation Absent 7B No expression in differentiating cartilage and bone.
TS21: foot epithelium Present Regionally restricted 7B No expression in distal regions (footplates) except in surface ectoderm.
TS21: hindlimb interdigital region epithelium Strong 7B In surface ectoderm, higher expression in interdigital regions.
TS21: hindlimb interdigital region mesenchyme Weak 7B Weak expression in interdigital mesenchymal cells.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory