Hoxa11 RNA in situ Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:241982 Woltering JM, et al., Conservation and divergence of regulatory strategies at Hox Loci and the origin of tetrapod digits. PLoS Biol. 2014 Jan;12(1):e1001773
Assay type:	RNA in situ
MGI Accession ID:	MGI:5904290
Gene symbol:	Hoxa11
Gene name:	homeobox A11

Probe:	Hoxa11 probe7
Probe preparation:	Antisense labelled with digoxigenin RNA

Results

2A Hoxa11 ©

Specimen 2A Hoxa11: embryonic day 12.5 (more

)

Structure	Level	Pattern	Image	Note
TS20: forearm	Present	Regionally restricted	2A Hoxa11	Expression in distal zeugopod.
TS20: hand	Absent		2A Hoxa11	No expression only in presumptive digits.

Specimen 2B WT fl: embryonic day 12.5 (more

)

Structure	Level	Pattern	Image	Note
TS20: forearm	Present		2B Hoxa11 WT fl
TS20: hand	Absent		2B Hoxa11 WT fl

Specimen 2B WT hl: embryonic day 12.5 (more

)

Structure	Level	Pattern	Image	Note
TS20: lower leg	Present		2B Hoxa11 WT hl
TS20: foot	Absent		2B Hoxa11 WT hl

Specimen 2B Hoxa13-/- fl: embryonic day 12.5; Hoxa13^tm2Ipc/Hoxa13^tm2Ipc (more

)

Structure	Level	Pattern	Image	Note
TS20: forearm	Present		2B Hoxa11 Hoxa13-/- fl	Expression shifts distally.
TS20: hand	Present	Regionally restricted	2B Hoxa11 Hoxa13-/- fl	Expression extends into proximal autopod.

Specimen 2B Hoxa13-/- hl: embryonic day 12.5; Hoxa13^tm2Ipc/Hoxa13^tm2Ipc (more

)

Structure	Level	Pattern	Image	Note
TS20: lower leg	Present		2B Hoxa11 Hoxa13-/- hl	Expression shifts distally.
TS20: foot	Present	Regionally restricted	2B Hoxa11 Hoxa13-/- hl	Expression extends into proximal autopod.

Specimen 2B Hoxa13-/- Hoxd13-/- fl: embryonic day 12.5; Hoxa13^tm2Ipc/Hoxa13^tm2Ipc, Hoxd13^tm1Ddu/Hoxd13^tm1Ddu (more

)

Structure	Level	Pattern	Image	Note
TS20: forearm	Present		2B Hoxa11 Hoxa13-/- Hoxd13-/- fl	Expression spreads further distally.
TS20: hand	Present	Widespread	2B Hoxa11 Hoxa13-/- Hoxd13-/- fl	Expression almost throughout the developing autopod.

Specimen 2B Hoxa13-/- Hoxd13-/- hl: embryonic day 12.5; Hoxa13^tm2Ipc/Hoxa13^tm2Ipc, Hoxd13^tm1Ddu/Hoxd13^tm1Ddu (more

)

Structure	Level	Pattern	Image	Note
TS20: lower leg	Present		2B Hoxa11 Hoxa13-/- Hoxd13-/- hl	Expression spreads further distally.
TS20: foot	Present	Widespread	2B Hoxa11 Hoxa13-/- Hoxd13-/- hl	Expression almost throughout the developing autopod.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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