Cdh5 Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:243789 Chang AH, et al., DACH1 stimulates shear stress-guided endothelial cell migration and coronary artery growth through the CXCL12-CXCR4 signaling axis. Genes Dev. 2017 Aug 04;31(13):1308-1324
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:6107786
Gene symbol:	Cdh5
Gene name:	cadherin 5

Antibody:	clone 11D4-1
Detection system:	Secondary antibody coupled to Alexa Fluor

Results

1A middle left ©

1A upper left ©

Specimen 1A e17.5 WT: embryonic day 17.5 (more

)

Structure	Level	Image	Note
TS25: coronary artery	Present	1A middle left , 1A upper left	Expressed in endothelial cells.
TS25: blood vessel endothelium	Present	1A middle left , 1A upper left
TS25: heart	Present	1A middle left , 1A upper left

1A middle right ©

1A upper right ©

Specimen 1A e17.5 KO: embryonic day 17.5; Dach1^tm1Mrd/Dach1^tm1Mrd (more

)

Structure	Level	Image	Note
TS25: coronary artery	Present	1A upper right , 1A middle right	Expressed in endothelial cells.
TS25: blood vessel endothelium	Present	1A middle right , 1A upper right
TS25: heart	Present	1A middle right , 1A upper right

1A lower left ©

Specimen 1A P0 WT: postnatal day 0 (more

)

Structure	Level	Image	Note
TS27: coronary artery	Present	1A lower left	Expressed in endothelial cells.
TS27: blood vessel endothelium	Present	1A lower left
TS27: heart	Present	1A lower left

1A lower right ©

Specimen 1A P0 KO: postnatal day 0; Dach1^tm1Mrd/Dach1^tm1Mrd (more

)

Structure	Level	Image	Note
TS27: coronary artery	Present	1A lower right	Expressed in endothelial cells.
TS27: blood vessel endothelium	Present	1A lower right
TS27: heart	Present	1A lower right

1H left ©

Specimen 1H WT: embryonic day 17.5 (more

)

Structure	Level	Pattern	Image	Note
TS25: heart	Present		1H left

1H right ©

Specimen 1H KO: embryonic day 17.5; Dach1^tm1Mrd/Dach1^tm1Mrd (more

)

Structure	Level	Pattern	Image	Note
TS25: heart	Present		1H right	Same as the wild-type.

2B left ©

2B right merge ©

2B right VE ©

Specimen 2B: embryonic day 14.5 (more

)

Structure	Level	Pattern	Image	Note
TS22: coronary artery	Present	Non-Uniform	2B right merge , 2B right VE , 2B left	Expressed in endothelial cells.
TS22: heart	Present		2B right VE , 2B right merge , 2B left

2C left ©

2C right merge ©

2C right VE ©

Specimen 2C: embryonic day 15.5 (more

)

Structure	Level	Pattern	Image	Note
TS23: coronary artery	Present		2C left , 2C right merge , 2C right VE	Expressed in endothelial cells.
TS23: heart	Present		2C right VE , 2C left , 2C right merge

2D left ©

2D right merge ©

2D right VE ©

Specimen 2D: embryonic day 16.5 (more

)

Structure	Level	Pattern	Image	Note
TS24: coronary artery	Present		2D right VE , 2D left , 2D right merge	Expressed in endothelial cells.
TS24: heart	Present		2D right VE , 2D right merge , 2D left

2E left ©

Specimen 2E: postnatal adult (more

)

Structure	Level	Pattern	Image	Note
TS28: coronary artery	Present		2E left	Expressed in endothelial cells.
TS28: heart	Present		2E left

3A upper left ©

Specimen 3A Control: embryonic day 15.5 (more

)

Structure	Level	Pattern	Image	Note
TS23: coronary artery	Present		3A upper left	Expressed in endothelial cells.
TS23: heart	Present		3A upper left

3A lower left ©

Specimen 3A eCKO: embryonic day 15.5; Dach1^{tm1c(KOMP)Wtsi}/Dach1^{tm1c(KOMP)Wtsi}, Tg(Tek-cre)12Flv/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS23: coronary artery	Present		3A lower left	Expressed in endothelial cells.
TS23: heart	Present		3A lower left

3B left ©

Specimen 3B Control: embryonic day 17.5 (more

)

Structure	Level	Pattern	Image	Note
TS25: coronary artery	Present		3B left	Expressed in endothelial cells.
TS25: heart	Present		3B left

3B right ©

Specimen 3B eCKO: embryonic day 17.5; Dach1^{tm1c(KOMP)Wtsi}/Dach1^{tm1c(KOMP)Wtsi}, Tg(Tek-cre)12Flv/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS25: coronary artery	Present		3B right	Expressed in endothelial cells.

3E left ©

Specimen 3E Early RZ: embryonic day 15.5; Dach1^tm1Mrd/Dach1^tm1Mrd (more

)

Structure	Level	Pattern	Image	Note
TS23: coronary artery	Present		3E left	Expressed in endothelial cells of the early arterial remodeling zone.
TS23: heart	Present		3E left

3E middle ©

Specimen 3E Late RZ: embryonic day 15.5 (more

)

Structure	Level	Pattern	Image	Note
TS23: coronary artery	Present		3E middle	Expressed in endothelial cells in the late arterial remodeling zone.
TS23: heart	Present		3E middle

3E right ©

Specimen 3E Mature CA: embryonic day 15.5 (more

)

Structure	Level	Pattern	Image	Note
TS23: coronary artery	Present		3E right	Expressed in endothelial cells.
TS23: heart	Present		3E right

5C upper merge ©

5C upper VE ©

Specimen 5C upper: embryonic day 16.5; Cxcl12^tm2.1Sjm/Cxcl12⁺ (more

)

Structure	Level	Pattern	Image	Note
TS24: coronary artery	Present		5C upper merge , 5C upper VE	Expressed in endothelial cells.
TS24: heart	Present		5C upper merge , 5C upper VE

5C lower VE ©

Specimen 5C lower: embryonic day 16.5; Cxcl12^tm2.1Sjm/Cxcl12⁺, Dach1^tm1Mrd/Dach1^tm1Mrd (more

)

Structure	Level	Pattern	Image	Note
TS24: coronary artery	Present		5C lower VE , 5C lower merge	Expressed in endothelial cells.
TS24: heart	Present		5C lower VE , 5C lower merge

7D upper ©

Specimen 7D: postnatal day 16 (more

)

Structure	Level	Pattern	Image	Note
TS28: retinal artery	Present		7D upper	Expressed in endothelial cells.

7F upper ©

Specimen 7F: postnatal day 0 (more

)

Structure	Level	Pattern	Image	Note
TS27: coronary artery	Present		7F upper	Expressed in endothelial cells.
TS27: heart	Present		7F upper

S2_left ©

S2_middle ©

Specimen S2: postnatal day 8 (more

)

Structure	Level	Image	Note
TS28: retina blood vessel	Present	S2_left , S2_right lower , S2_middle , S2_right upper	Expressed in endothelial cells.
TS28: retinal artery	Present	S2_left , S2_right lower , S2_middle , S2_right upper	Expressed in endothelial cells.
TS28: retinal vein	Present	S2_left , S2_right lower , S2_middle , S2_right upper	Expressed in endothelial cells.

Specimen S6B P10: postnatal day 10 (more

)

Structure	Level	Pattern	Image	Note
TS28: retinal artery	Present		S6B upper middle , S6B upper left	Expressed in endothelial cells.

Specimen S6B Adult: postnatal adult (more

)

Structure	Level	Pattern	Image	Note
TS28: retinal artery	Present		S6B lower left , S6B lower middle	Expressed in endothelial cells.

Specimen not shown: embryonic day 13.5 (more

)

Structure	Level	Pattern	Image	Note
TS21: coronary artery	Present			Expressed in endothelial cells.
TS21: heart	Present

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