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Gene Expression Data
Assay Details
Assay
Reference: J:243789 Chang AH, et al., DACH1 stimulates shear stress-guided endothelial cell migration and coronary artery growth through the CXCL12-CXCR4 signaling axis. Genes Dev. 2017 Aug 04;31(13):1308-1324
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6107838
Gene symbol: Myh11
Gene name: myosin, heavy polypeptide 11, smooth muscle
Antibody: anti-SM-MHC (bt-562)
Detection system: Secondary antibody coupled to Alexa Fluor
Results
Specimen 1A e17.5 WT: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: coronary artery Present Regionally restricted 1A upper left , 1A middle left Expressed in the smooth muscle cells that surround mature coronary arteries.
TS25: artery smooth muscle Present 1A upper left , 1A middle left
Specimen 1A e17.5 KO: embryonic day 17.5; Dach1tm1Mrd/Dach1tm1Mrd (more )
Structure Level Pattern Image Note
TS25: coronary artery Present Regionally restricted 1A upper right , 1A middle right Expressed in the smooth muscle cells that surround mature coronary arteries, which were smaller in diameter and exhibited abnormal looping structures.
TS25: artery smooth muscle Present 1A upper right , 1A middle right
Specimen 1A P0 WT: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: coronary artery Present Regionally restricted 1A lower left Expressed in the smooth muscle cells that surround mature coronary arteries.
TS27: artery smooth muscle Present 1A lower left
Specimen 1A P0 KO: postnatal day 0; Dach1tm1Mrd/Dach1tm1Mrd (more )
Structure Level Pattern Image Note
TS27: coronary artery Present Regionally restricted 1A lower right Expressed in the smooth muscle cells that surround mature coronary arteries, which were smaller in diameter and exhibited abnormal looping structures.
TS27: artery smooth muscle Present 1A lower right
Specimen 3B Control: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: coronary artery Present Regionally restricted 3B left Expressed in the smooth muscle cells that surround mature coronary arteries.
TS25: artery smooth muscle Present 3B left
Specimen 3B eCKO: embryonic day 17.5; Dach1tm1c(KOMP)Wtsi/Dach1tm1c(KOMP)Wtsi, Tg(Tek-cre)12Flv/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS25: coronary artery Present Regionally restricted 3B right Expressed in the smooth muscle cells that surround mature coronary arteries, which were smaller in diameter and exhibited abnormal looping structures.
TS25: artery smooth muscle Present 3B right
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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06/12/2024
MGI 6.13 		The Jackson Laboratory