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Gene Expression Data
Assay Details
Assay
Reference: J:119175 Donner AL, et al., Sox2 and Pou2f1 interact to control lens and olfactory placode development. Dev Biol. 2007 Mar 15;303(2):784-799
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6159121
Gene symbol: Pax6
Gene name: paired box 6
Antibody: anti-Pax6
Detection system: Cy3
Results
Specimen 2A: embryonic day 8.5 (more )
Note: 12 somites.
Structure Level Pattern Image Note
TS13: eye surface ectoderm Present Regionally restricted 2A Authors report expression in presumptive lens ectoderm at 12-somite stage.
Specimen 2B: embryonic day 9.0 (more )
Note: 15 somites.
Structure Level Pattern Image Note
TS14: lens pre-placode Present 2B Authors maintained in presumptive lens ectoderm at subsequent stages.
Specimen 2C: embryonic day 9.0 (more )
Note: 17 somites.
Structure Level Pattern Image Note
TS14: lens pre-placode Present 2C Authors maintained in presumptive lens ectoderm at subsequent stages.
Specimen 3A,C: embryonic day 9.5 (more )
Note: Double labeled: red - Pax6; green - Sox2 (assay MGI:6159122).
Structure Level Pattern Image Note
TS15: lens placode Present 3C , 3A
Specimen 3D,F: embryonic day 11.5 (more )
Note: Double labeled: red - Pax6; green - Sox2 (assay MGI:6159122).
Structure Level Pattern Image Note
TS19: lens vesicle Present 3D , 3F Expression throughout placode invagination and lens vesicle formation.
Specimen not shown: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: lens anterior epithelium Present Upon differentiation, expression maintained in the anterior epithelial layer.
TS21: posterior lens fiber Weak Regionally restricted Expression down-regulated in fiber cells of posterior lens.
Specimen S2A: embryonic day 9.5; Sox2tm1.1Vep/Sox2+ (more )
Structure Level Pattern Image Note
TS15: lens placode Present S2A
Specimen S2B: embryonic day 9.5; Pax6Sey-Neu/Pax6+ (more )
Structure Level Pattern Image Note
TS15: lens placode Present S2B
Specimen S2C: embryonic day 9.5; Pax6Sey-Neu/Pax6+, Sox2tm1.1Vep/Sox2+ (more )
Structure Level Pattern Image Note
TS15: lens placode Present S2C Authors report compound mutant embryos had patterns of expression indistinguishable from those of Sox2 +/- or Pax6 Sey/+ single heterozygous mutants.
Specimen S2D: embryonic day 11.5; Sox2tm1.1Vep/Sox2+ (more )
Structure Level Pattern Image Note
TS19: lens vesicle Present S2D
Specimen S2E: embryonic day 11.5; Pax6Sey-Neu/Pax6+ (more )
Structure Level Pattern Image Note
TS19: lens vesicle Present S2E
Specimen S2F: embryonic day 11.5; Pax6Sey-Neu/Pax6+, Sox2tm1.1Vep/Sox2+ (more )
Structure Level Pattern Image Note
TS19: lens vesicle Present S2F Authors report compound mutant embryos had patterns of expression indistinguishable from those of Sox2 +/- or Pax6 Sey/+ single heterozygous mutants.
Specimen S2G: embryonic day 13.5; Sox2tm1.1Vep/Sox2+ (more )
Structure Level Pattern Image Note
TS21: lens Present S2G
Specimen S2H: embryonic day 13.5; Pax6Sey-Neu/Pax6+ (more )
Structure Level Pattern Image Note
TS21: lens Present S2H
Specimen S2I: embryonic day 13.5; Pax6Sey-Neu/Pax6+, Sox2tm1.1Vep/Sox2+ (more )
Structure Level Pattern Image Note
TS21: lens Present S2I Authors report compound mutant embryos had patterns of expression indistinguishable from those of Sox2 +/- or Pax6 Sey/+ single heterozygous mutants.
Specimen S2J: embryonic day 9.5; Pou2f1tm1Shrp/Pou2f1+ (more )
Structure Level Pattern Image Note
TS15: lens placode Present S2J
Specimen S2K: embryonic day 9.5; Pou2f1tm1Shrp/Pou2f1+, Sox2tm1.1Vep/Sox2+ (more )
Structure Level Pattern Image Note
TS15: lens placode Present S2K Authors report normal patterns of expression in compound mutant embryos.
Specimen S2L: embryonic day 11.5; Pou2f1tm1Shrp/Pou2f1+ (more )
Structure Level Pattern Image Note
TS19: lens vesicle Present S2L
Specimen S2M: embryonic day 11.5; Pou2f1tm1Shrp/Pou2f1+, Sox2tm1.1Vep/Sox2+ (more )
Structure Level Pattern Image Note
TS19: lens vesicle Present S2M Authors report normal patterns of expression in compound mutant embryos.
Specimen S4A: embryonic day 11.5; Pou2f1tm1Shrp/Pou2f1tm1Shrp (more )
Structure Level Pattern Image Note
TS19: eye Present S4A
Specimen S4C: embryonic day 11.5; Pou2f1tm1Shrp/Pou2f1tm1Shrp, Sox2tm1.1Vep/Sox2+ (more )
Structure Level Pattern Image Note
TS19: eye Present S4C
Specimen S4E: embryonic day 11.5; Pou2f1tm1Shrp/Pou2f1tm1Shrp, Sox2tm1.1Vep/Sox2+ (more )
Structure Level Pattern Image Note
TS19: eye Present S4E
Specimen S4G: embryonic day 11.5; Pax6Sey-Neu/Pax6Sey-Neu (more )
Structure Level Pattern Image Note
TS19: eye Absent S4G
Specimen S4K: embryonic day 12.5; Pou2f1tm1Shrp/Pou2f1tm1Shrp, Sox2tm1.1Vep/Sox2+ (more )
Structure Level Pattern Image Note
TS20: eye Present S4K
Specimen S4L: embryonic day 12.5; Pou2f1tm1Shrp/Pou2f1tm1Shrp, Sox2tm1.1Vep/Sox2+ (more )
Structure Level Pattern Image Note
TS20: eye Present S4L
Specimen 4A: embryonic day 9.0 (more )
Structure Level Pattern Image Note
TS14: olfactory placode Present 4A Expression in nasal placode.
Specimen 4D: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: nasal pit Present 4D Expression in most cells of nasal pit.
Specimen 7F: embryonic day 10.5; Pou2f1tm1Shrp/Pou2f1tm1Shrp (more )
Structure Level Pattern Image Note
TS17: olfactory placode Present 7F Authors state nasal placodes were induced and expression was normal.
Specimen 7H: embryonic day 10.5; Pax6Sey-Neu/Pax6Sey-Neu (more )
Structure Level Pattern Image Note
TS17: olfactory placode Absent 7H
Specimen 7I: embryonic day 10.5; Pou2f1tm1Shrp/Pou2f1tm1Shrp, Sox2tm1.1Vep/Sox2+ (more )
Structure Level Pattern Image Note
TS17: olfactory placode Absent 7I
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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06/12/2024
MGI 6.13 		The Jackson Laboratory