Rbpms Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:256989 King R, et al., Genomic locus modulating corneal thickness in the mouse identifies POU6F2 as a potential risk of developing glaucoma. PLoS Genet. 2018 Jan;14(1):e1007145
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:6187964
Gene symbol:	Rbpms
Gene name:	RNA binding protein gene with multiple splicing

Antibody:	anti-RBPMS (ABN1376)
Detection system:	Alexa Fluor 488

Results

7B ©

7D ©

Specimen 7B/D: postnatal adult (more

)
Note: Flat mount. Triple labeled: red - Rbpms; green - Pou6f2 (assay MGI:6187963); blue - TOPRO-3.

Structure	Level	Pattern	Image	Note
TS28: retina ganglion cell layer	Present	Widespread	7B , 7D	Expression in virtually all Pou6f2-positive ganglion cells.
TS28: retina inner nuclear layer	Weak		7B , 7D	Expression in few cells in inner nuclear layer.

Specimen Young D2: postnatal month 2 (more

)
Note: Data shown in Figure 8.

Structure	Level	Pattern	Image	Note
TS28: retina ganglion cell layer	Present

Specimen Aged D2: postnatal month 8 (more

)
Note: Data shown in Figure 8.

Structure	Level	Pattern	Image	Note
TS28: retina ganglion cell layer	Weak			Authors report a 22% loss of expressing retinal ganglion cells (RGCs) in aged DBA/2J mice compared to young DBA/2J mice.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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