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Gene Expression Data
Assay Details
Assay
Reference: J:229950 Fujita M, et al., Pharyngeal arch artery defects and lethal malformations of the aortic arch and its branches in mice deficient for the Hrt1/Hey1 transcription factor. Mech Dev. 2016 Feb;139:65-73
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6236304
Gene symbol: Pecam1
Gene name: platelet/endothelial cell adhesion molecule 1
Antibody: MEC 13.3
Results
Specimen 3a: embryonic day 10.5 (more )
Note: Double labeled: red - Pecam1; green - Tagln (assay MGI:6236305).
Structure Level Pattern Image Note
TS17: 4th arch artery Present Regionally restricted 3a' , 3a , 3a'' Expression was detected in the 4th pharyngeal arch artery endothelium.
TS17: artery endothelium Present Regionally restricted 3a' , 3a , 3a'' Expression was detected in the 4th pharyngeal arch artery endothelium.
Specimen 3b: embryonic day 10.5; Hey1tm1Ona/Hey1tm1Ona (more )
Note: Structurally intact. Double labeled: red - Pecam1; green - Tagln (assay MGI:6236305).
Structure Level Pattern Image Note
TS17: 4th arch artery Present Regionally restricted 3b' , 3b , 3b'' Expression was maintained in the mutant 4th pharyngeal arch artery endothelium.
TS17: artery endothelium Present Regionally restricted 3b' , 3b , 3b'' Expression was maintained in the mutant 4th pharyngeal arch artery endothelium.
Specimen 3c: embryonic day 10.5; Hey1tm1Ona/Hey1tm1Ona (more )
Note: Structurally defective. Double labeled: red - Pecam1; green - Tagln (assay MGI:6236305).
Structure Level Pattern Image Note
TS17: 4th arch artery Present Regionally restricted 3c' , 3c'' , 3c Even in the defective structure, expression was maintained in the mutant 4th pharyngeal arch artery endothelium.
TS17: artery endothelium Present Regionally restricted 3c' , 3c'' , 3c Even in the defective structure, expression was maintained in the mutant 4th pharyngeal arch artery endothelium.
Specimen 3d: embryonic day 11.5 (more )
Note: Double labeled: red - Pecam1; green - Tagln (assay MGI:6236305).
Structure Level Pattern Image Note
TS19: 4th arch artery Present Regionally restricted 3d'' , 3d , 3d' Expression was detected in the 4th pharyngeal arch artery endothelium.
TS19: artery endothelium Present Regionally restricted 3d'' , 3d , 3d' Expression was detected in the 4th pharyngeal arch artery endothelium.
Specimen 3e: embryonic day 11.5; Hey1tm1Ona/Hey1tm1Ona (more )
Note: Structurally intact. Double labeled: red - Pecam1; green - Tagln (assay MGI:6236305).
Structure Level Pattern Image Note
TS19: 4th arch artery Present Regionally restricted 3e' , 3e , 3e'' Expression was maintained in the mutant 4th pharyngeal arch artery endothelium.
TS19: artery endothelium Present Regionally restricted 3e' , 3e , 3e'' Expression was maintained in the mutant 4th pharyngeal arch artery endothelium.
Specimen 3f: embryonic day 11.5; Hey1tm1Ona/Hey1tm1Ona (more )
Note: Structurally defective. Double labeled: red - Pecam1; green - Tagln (assay MGI:6236305).
Structure Level Pattern Image Note
TS19: 4th arch artery Present Regionally restricted 3f' , 3f'' , 3f Even in the defective structure, expression was maintained in the mutant 4th pharyngeal arch artery endothelium.
TS19: artery endothelium Present Regionally restricted 3f' , 3f'' , 3f Even in the defective structure, expression was maintained in the mutant 4th pharyngeal arch artery endothelium.
Specimen 5Ca: embryonic day 11.5 (more )
Note: Double labeled: red - Pecam1; green - Jag1 (assay MGI:6256467).
Structure Level Pattern Image Note
TS19: 4th arch artery Present Regionally restricted 5Ca , 5Ca'' Expression was detected in the 4th pharyngeal arch artery endothelium.
TS19: artery endothelium Present Regionally restricted 5Ca , 5Ca'' Expression was detected in the 4th pharyngeal arch artery endothelium.
Specimen 5Cb: embryonic day 11.5; Hey1tm1Ona/Hey1tm1Ona (more )
Note: Structurally intact. Double labeled: red - Pecam1; green - Jag1 (assay MGI:6256467).
Structure Level Pattern Image Note
TS19: 4th arch artery Present Regionally restricted 5Cb'' , 5Cb Expression was maintained in the mutant 4th pharyngeal arch artery endothelium.
TS19: artery endothelium Present Regionally restricted 5Cb'' , 5Cb Expression was maintained in the mutant 4th pharyngeal arch artery endothelium.
Specimen 5Cc: embryonic day 11.5; Hey1tm1Ona/Hey1tm1Ona (more )
Note: Structurally defective. Double labeled: red - Pecam1; green - Jag1 (assay MGI:6256467).
Structure Level Pattern Image Note
TS19: 4th arch artery Present Regionally restricted 5Cc , 5Cc'' Even in the defective structure, expression was maintained in the mutant 4th pharyngeal arch artery endothelium. This is in contrast to expression of Jag1, which was severely reduced.
TS19: artery endothelium Present Regionally restricted 5Cc , 5Cc'' Even in the defective structure, expression was maintained in the mutant 4th pharyngeal arch artery endothelium. This is in contrast to expression of Jag1, which was severely reduced.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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06/12/2024
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