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Gene Expression Data
Assay Details
Assay
Reference: J:266915 Bonet F, et al., CCBE1 is required for coronary vessel development and proper coronary artery stem formation in the mouse heart. Dev Dyn. 2018 Oct;247(10):1135-1145
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6270372
Gene symbol: Cdh5
Gene name: cadherin 5
Antibody: clone 11D4-1
Detection system: Secondary antibody
Results
Specimen 5A WT E12.5: embryonic day 12.5 (more )
Note: Double labeled: blue - Cdh5; red - alpha-Actinin.
Structure Level Pattern Image Note
TS20: ascending aorta Present 5A upper left
TS20: coronary vascular plexus Present 5A upper left
Specimen 5A KO E12.5: embryonic day 12.5; Ccbe1tm1Lex/Ccbe1tm1Lex (more )
Note: Double labeled: blue - Cdh5; red - alpha-Actinin.
Structure Level Pattern Image Note
TS20: ascending aorta Present 5A lower left
TS20: coronary vascular plexus Present Regionally restricted 5A lower left Peritruncal vessel growth was severely reduced.
Specimen 5A WT E13.5: embryonic day 13.5 (more )
Note: Double labeled: blue - Cdh5; red - alpha-Actinin.
Structure Level Pattern Image Note
TS21: ascending aorta Present 5A upper right
TS21: coronary artery Present 5A upper right
Specimen 5A KO E13.5: embryonic day 13.5; Ccbe1tm1Lex/Ccbe1tm1Lex (more )
Note: Double labeled: blue - Cdh5; red - alpha-Actinin.
Structure Level Pattern Image Note
TS21: ascending aorta Present 5A lower right
TS21: coronary artery Present Regionally restricted 5A lower right Peritruncal vessel growth was severely reduced.
Specimen 5B WT E12.5: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: ascending aorta Present 5B upper left
TS20: coronary vascular plexus Present 5B upper left
Specimen 5B KO E12.5: embryonic day 12.5; Ccbe1tm1Lex/Ccbe1tm1Lex (more )
Structure Level Pattern Image Note
TS20: ascending aorta Present 5B lower left
TS20: coronary vascular plexus Present Regionally restricted 5B lower left Coronary artery stems were absent.
Specimen 5B WT E13.5: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: ascending aorta Present 5B upper middle
TS21: coronary artery Present 5B upper middle
Specimen 5B KO E13.5: embryonic day 13.5; Ccbe1tm1Lex/Ccbe1tm1Lex (more )
Structure Level Pattern Image Note
TS21: ascending aorta Present 5B lower middle
TS21: coronary artery Present Regionally restricted 5B lower middle Coronary artery stems were absent.
Specimen 5B WT E14.0: embryonic day 14.0 (more )
Structure Level Pattern Image Note
TS22: ascending aorta Present 5B upper right
TS22: coronary artery Present 5B upper right
Specimen 5B KO E14.0: embryonic day 14.0; Ccbe1tm1Lex/Ccbe1tm1Lex (more )
Structure Level Pattern Image Note
TS22: ascending aorta Present 5B lower right
TS22: coronary artery Present 5B lower right Coronary artery was mostly abnormally connected to the aorta.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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06/12/2024
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