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Gene Expression Data
Assay Details
Assay
Reference: J:175544 Dupuis LE, et al., Altered versican cleavage in ADAMTS5 deficient mice; A novel etiology of myxomatous valve disease. Dev Biol. 2011 Sep 1;357(1):152-64
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:6279795
Gene symbol: Adamts5
Gene name: ADAM metallopeptidase with thrombospondin type 1 motif 5
Reporter: lacZ
Direct Detection
Results
Specimen 1B: embryonic day 12.5; Adamts5tm1Dgen/Adamts5+ (more )
Structure Level Pattern Image Note
TS20: outflow tract endocardial cushion Present Regionally restricted 1B Authors state reporter expression was first detected in endocardial cushions of developing valves in a subset of embryos at E12.5 in the endocardium.
Specimen 1F: embryonic day 14.5; Adamts5tm1Dgen/Adamts5+ (more )
Structure Level Pattern Image Note
TS22: pulmonary valve Present Regionally restricted 1F Expression in endocardium of pulmonary valve cusps.
TS22: ascending aorta Present Regionally restricted 1F Expression in walls of great arteries.
TS22: pulmonary artery Present Regionally restricted 1F Expression in walls of great arteries.
Specimen 1G: embryonic day 14.5; Adamts5tm1Dgen/Adamts5+ (more )
Structure Level Pattern Image Note
TS22: aortic valve Present Regionally restricted 1G Expression in endocardium of aortic valve cusps. Expression in mesenchymal cells of the hinge region.
Specimen 1H: embryonic day 14.5; Adamts5tm1Dgen/Adamts5+ (more )
Structure Level Pattern Image Note
TS22: semilunar valve Present Regionally restricted 1H Expression mesenchymal cells of semilunar valves in hinge region of maturing cusps.
Specimen 1K: embryonic day 17.5; Adamts5tm1Dgen/Adamts5+ (more )
Structure Level Pattern Image Note
TS25: cardiac valve leaflet Present Regionally restricted 1K Expression in valvular endocardium, most readily detected on ventricular aspect of outflow valve cusps.
Specimen 1L: embryonic day 17.5; Adamts5tm1Dgen/Adamts5+ (more )
Structure Level Pattern Image Note
TS25: cardiac valve leaflet Present Regionally restricted 1L Expression in valvular endocardium, most readily detected on ventricular aspect of outflow valve cusps.
TS25: semilunar valve Present Regionally restricted 1L Expression mesenchymal cells of semilunar valves in hinge region of maturing cusps.
Specimen 1M: embryonic day 17.5; Adamts5tm1Dgen/Adamts5+ (more )
Structure Level Pattern Image Note
TS25: aortic valve leaflet Present Regionally restricted 1M Expression in valvular endocardium, most readily detected on ventricular aspect of outflow valve cusps.
Specimen 1P: postnatal adult; Adamts5tm1Dgen/Adamts5+ (more )
Structure Level Pattern Image Note
TS28: pulmonary valve Present 1P
Specimen 1R: postnatal adult; Adamts5tm1Dgen/Adamts5+ (more )
Structure Level Pattern Image Note
TS28: aortic valve Present 1R
Specimen 1T: postnatal adult; Adamts5tm1Dgen/Adamts5+ (more )
Structure Level Pattern Image Note
TS28: mitral valve Present 1T
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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09/17/2024
MGI 6.24 		The Jackson Laboratory