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Gene Expression Data
Assay Details
Assay
Reference: J:175544 Dupuis LE, et al., Altered versican cleavage in ADAMTS5 deficient mice; A novel etiology of myxomatous valve disease. Dev Biol. 2011 Sep 1;357(1):152-64
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6279796
Gene symbol: Adamts5
Gene name: ADAM metallopeptidase with thrombospondin type 1 motif 5
Results
Specimen 1C: embryonic day 12.5 (more )
Note: Triple labeled: green - Adamts5; blue - Acta1 (sarcomeric actin; assay MGI:6279797); red - propidium iodide.
Structure Level Pattern Image Note
TS20: outflow tract cardiac muscle Strong Regionally restricted 1C Expression most intense surrounding developing pulmonary valve cushions.
Specimen 1D: embryonic day 12.5 (more )
Note: Triple labeled: green - Adamts5; blue - Acta1 (sarcomeric actin; assay MGI:6279797); red - propidium iodide.
Structure Level Pattern Image Note
TS20: outflow tract cardiac muscle Weak Regionally restricted 1D Expression was less intense but evident in myocardium surrounding developing aortic valve.
Specimen 1E: embryonic day 13.5 (more )
Note: Double labeled: green - Adamts5; red - propidium iodide.
Structure Level Pattern Image Note
TS21: heart valve Present Regionally restricted 1E Author state expression was first detected developing valves by immunolocalization at E13.5 in the extracellular matrix of the endocardium.
TS21: cardiac muscle tissue Strong Regionally restricted 1E Strong expression in underlying myocardium.
TS21: outflow tract endocardial cushion Very strong Regionally restricted 1E Expression most intense surrounding developing pulmonary valve cushions.
Specimen 1Q: postnatal adult (more )
Note: Double labeled: green - Adamts5; red - propidium iodide.
Structure Level Pattern Image Note
TS28: heart valve Present Regionally restricted 1Q Expression throughout cusps of adult cardiac valves. Expression localized within valvular interstitial cells and extracellular matrix of the distal cusp and annulus.
Specimen 1S: postnatal adult (more )
Note: Double labeled: green - Adamts5; red - propidium iodide.
Structure Level Pattern Image Note
TS28: heart valve Present Regionally restricted 1S Expression throughout cusps of adult cardiac valves. Expression localized within valvular interstitial cells and extracellular matrix of the distal cusp and annulus.
TS28: heart anulus fibrosus Present 1S
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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09/17/2024
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