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Gene Expression Data
Assay Details
Assay
Reference: J:188806 Hurd EA, et al., Delayed fusion and altered gene expression contribute to semicircular canal defects in Chd7 deficient mice. Mech Dev. 2012 Sep;129(9-12):308-23
Assay type: RNA in situ
MGI Accession ID: MGI:6305193
Gene symbol: Bmp4
Gene name: bone morphogenetic protein 4
Probe: Bmp4 probe59
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 9K: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted 9K Expression was detected in anterior crista primordia.
Specimen 9L: embryonic day 10.5; Chd7Gt(S20-7E1)Sor/Chd7+ (more )
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted 9L Expression was detected in anterior crista primordia.
Specimen 9M: embryonic day 10.5; Chd7Gt(S20-7E1)Sor/Chd7Gt(S20-7E1)Sor (more )
Structure Level Pattern Image Note
TS17: otocyst Absent 9M
Specimen 9N: embryonic day 10.5; Chd7tm1.1Dmm/Chd7+, Foxg1tm1(cre)Skm/Foxg1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted 9N Expression was detected in anterior crista primordia.
Specimen 9O: embryonic day 10.5; Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm, Foxg1tm1(cre)Skm/Foxg1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Absent 9O
Specimen 9P: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted 9P Expression was detected in posterior crista primordia.
Specimen 9Q: embryonic day 10.5; Chd7Gt(S20-7E1)Sor/Chd7+ (more )
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted 9Q Expression was detected in posterior streak (variably, but in the majority N=4/6).
Specimen 9R: embryonic day 10.5; Chd7Gt(S20-7E1)Sor/Chd7Gt(S20-7E1)Sor (more )
Structure Level Pattern Image Note
TS17: otocyst Absent 9R
Specimen 9S: embryonic day 10.5; Chd7tm1.1Dmm/Chd7+, Foxg1tm1(cre)Skm/Foxg1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted 9S Expression was detected in posterior streak (variably).
Specimen 9T: embryonic day 10.5; Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm, Foxg1tm1(cre)Skm/Foxg1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Absent 9T
Specimen 10A: embryonic day 11.5; Chd7tm1.1Dmm/Chd7+ (more )
Structure Level Pattern Image Note
TS19: semicircular canal Present Regionally restricted 10A Expression was detected in the lateral cristae.
Specimen 10G: embryonic day 11.5; Chd7tm1.1Dmm/Chd7+, Foxg1tm1(cre)Skm/Foxg1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: semicircular canal Present Regionally restricted 10G Expression was detected in the lateral cristae.
Specimen 10M: embryonic day 11.5; Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm (more )
Structure Level Pattern Image Note
TS19: semicircular canal Ambiguous Regionally restricted 10M Expression was variably absent from the lateral cristae in N=2/4 mutant embryos.
Specimen 10S: embryonic day 11.5; Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm, Foxg1tm1(cre)Skm/Foxg1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: semicircular canal Absent 10S No expression was detected in the dorsal compartment of the conditional mutant inner ears.
Specimen S2A: embryonic day 12.5; Chd7tm1.1Dmm/Chd7+ (more )
Structure Level Pattern Image Note
TS21: lateral semicircular canal Present Regionally restricted S2A Expression was detected in the lateral cristae.
Specimen S2B: embryonic day 12.5; Chd7tm1.1Dmm/Chd7+, Foxg1tm1(cre)Skm/Foxg1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: lateral semicircular canal Present Regionally restricted S2B Expression was detected in the lateral cristae.
Specimen S2C: embryonic day 12.5; Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm (more )
Structure Level Pattern Image Note
TS21: lateral semicircular canal Ambiguous Regionally restricted S2C Expression was variably absent from the lateral cristae in N=2/4 mutant embryos.
Specimen S2D: embryonic day 12.5; Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm, Foxg1tm1(cre)Skm/Foxg1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: lateral semicircular canal Absent S2D No expression was detected in the dorsal compartment of the conditional mutant inner ears.
Specimen Table 1 +/+ E10.5: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: inner ear Present Expression was present in anterior, posterior and lateral regions.
Specimen Table 1 Gt/+ E10.5: embryonic day 10.5; Chd7Gt(S20-7E1)Sor/Chd7+ (more )
Structure Level Pattern Image Note
TS17: inner ear Present Regionally restricted Expression was present in anterior inner ear, but was variable in the posterior region.
Specimen Table 1 Gt/Gt E10.5: embryonic day 10.5; Chd7Gt(S20-7E1)Sor/Chd7Gt(S20-7E1)Sor (more )
Structure Level Pattern Image Note
TS17: inner ear Absent
Specimen Table 1 Cond. het E10.5: embryonic day 10.5; Chd7tm1.1Dmm/Chd7+, Foxg1tm1(cre)Skm/Foxg1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: inner ear Present Regionally restricted Expression was present in anterior and posterior regions.
Specimen Table 1 CKO E10.5: embryonic day 10.5; Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm, Foxg1tm1(cre)Skm/Foxg1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: inner ear Absent
Specimen Table 1 +/+ E11.5: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: inner ear Present Expression was present in anterior, posterior and lateral regions.
Specimen Table 1 Gt/+ E11.5: embryonic day 11.5; Chd7Gt(S20-7E1)Sor/Chd7+ (more )
Structure Level Pattern Image Note
TS19: inner ear Present Regionally restricted Expression was present in anterior and posterior inner ear. Lateral expression was variable.
Specimen Table 1 Cond. het E11.5: embryonic day 11.5; Chd7tm1.1Dmm/Chd7+, Foxg1tm1(cre)Skm/Foxg1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: inner ear Present Expression was present in anterior, posterior and lateral regions.
Specimen Table 1 CKO E11.5: embryonic day 11.5; Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm, Foxg1tm1(cre)Skm/Foxg1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: inner ear Absent
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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06/12/2024
MGI 6.13 		The Jackson Laboratory