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Gene Expression Data
Assay Details
Assay
Reference: J:188806 Hurd EA, et al., Delayed fusion and altered gene expression contribute to semicircular canal defects in Chd7 deficient mice. Mech Dev. 2012 Sep;129(9-12):308-23
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6305195
Gene symbol: Sox2
Gene name: SRY (sex determining region Y)-box 2
Antibody: anti-Sox2 (AB5603)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 9F: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Present 9F
Specimen 9G: embryonic day 10.5; Chd7Gt(S20-7E1)Sor/Chd7+ (more )
Structure Level Pattern Image Note
TS17: otocyst Present 9G
Specimen 9H: embryonic day 10.5; Chd7Gt(S20-7E1)Sor/Chd7Gt(S20-7E1)Sor (more )
Structure Level Pattern Image Note
TS17: otocyst Weak 9H
Specimen 9I: embryonic day 10.5; Chd7tm1.1Dmm/Chd7+, Foxg1tm1(cre)Skm/Foxg1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Present 9I Expression was detected in the otocyst, as in wild type.
Specimen 9J: embryonic day 10.5; Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm, Foxg1tm1(cre)Skm/Foxg1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Present 9J Expression was detected in the otocyst, as in wild type.
Specimen 10C: embryonic day 11.5; Chd7tm1.1Dmm/Chd7+ (more )
Structure Level Pattern Image Note
TS19: semicircular canal Present Regionally restricted 10C Expression was detected in the lateral cristae.
Specimen 10I: embryonic day 11.5; Chd7tm1.1Dmm/Chd7+, Foxg1tm1(cre)Skm/Foxg1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: semicircular canal Present Regionally restricted 10I Expression was detected in the lateral cristae.
Specimen 10O: embryonic day 11.5; Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm (more )
Structure Level Pattern Image Note
TS19: semicircular canal Present Regionally restricted 10O Expression was detected in the lateral cristae.
Specimen 10U: embryonic day 11.5; Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm, Foxg1tm1(cre)Skm/Foxg1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: semicircular canal Absent 10U No expression was detected in the dorsal compartment of the conditional mutant inner ears.
Specimen Table 1 +/+ E10.5: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: inner ear Present
Specimen Table 1 Gt/+ E10.5: embryonic day 10.5; Chd7Gt(S20-7E1)Sor/Chd7+ (more )
Structure Level Pattern Image Note
TS17: inner ear Present
Specimen Table 1 Gt/Gt E10.5: embryonic day 10.5; Chd7Gt(S20-7E1)Sor/Chd7Gt(S20-7E1)Sor (more )
Structure Level Pattern Image Note
TS17: inner ear Present
Specimen Table 1 Cond. het E10.5: embryonic day 10.5; Chd7tm1.1Dmm/Chd7+, Foxg1tm1(cre)Skm/Foxg1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: inner ear Present
Specimen Table 1 CKO E10.5: embryonic day 10.5; Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm, Foxg1tm1(cre)Skm/Foxg1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: inner ear Present
Specimen Table 1 +/+ E11.5: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: inner ear Present
Specimen Table 1 Gt/+ E11.5: embryonic day 11.5; Chd7Gt(S20-7E1)Sor/Chd7+ (more )
Structure Level Pattern Image Note
TS19: inner ear Present
Specimen Table 1 Cond. het E11.5: embryonic day 11.5; Chd7tm1.1Dmm/Chd7+, Foxg1tm1(cre)Skm/Foxg1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: inner ear Present
Specimen Table 1 CKO E11.5: embryonic day 11.5; Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm, Foxg1tm1(cre)Skm/Foxg1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: inner ear Absent
Specimen S2I: embryonic day 12.5; Chd7tm1.1Dmm/Chd7+ (more )
Structure Level Pattern Image Note
TS21: lateral semicircular canal Present Regionally restricted S2I Expression was detected in the lateral cristae.
Specimen S2J: embryonic day 12.5; Chd7tm1.1Dmm/Chd7+, Foxg1tm1(cre)Skm/Foxg1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: lateral semicircular canal Present Regionally restricted S2J Expression was detected in the lateral cristae.
Specimen S2K: embryonic day 12.5; Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm (more )
Structure Level Pattern Image Note
TS21: lateral semicircular canal Present Regionally restricted S2K Expression was detected in the lateral cristae.
Specimen S2L: embryonic day 12.5; Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm, Foxg1tm1(cre)Skm/Foxg1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: lateral semicircular canal Absent S2L No expression was detected in the dorsal compartment of the conditional mutant inner ears.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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06/12/2024
MGI 6.13 		The Jackson Laboratory