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Gene Expression Data
Assay Details
Assay
Reference: J:170258 Mavromatakis YE, et al., Foxa1 and Foxa2 positively and negatively regulate Shh signalling to specify ventral midbrain progenitor identity. Mech Dev. 2011 Jan-Feb;128(1-2):90-103
Assay type: RNA in situ
MGI Accession ID: MGI:6355399
Gene symbol: Ptch1
Gene name: patched 1
Results
Specimen 6A: embryonic day 9.5; Foxa2tm1Khk/Foxa2tm1Khk (more )
Note: Control.
Structure Level Pattern Image Note
TS15: future midbrain Present Regionally restricted 6A The ventral limit of expression was restricted to the alar/basal boundary.
Specimen 6A': embryonic day 9.5; Foxa2tm1Khk/Foxa2tm1Khk, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: future midbrain Present Regionally restricted 6A' In the conditional knockout the expression was shifted ventrally so that basal progenitors maintained expression.
Specimen 6B: embryonic day 10.5; Foxa2tm1Khk/Foxa2tm1Khk (more )
Note: Control. Posterior Midbrain.
Structure Level Pattern Image Note
TS17: midbrain Present Regionally restricted 6B The ventral limit of expression was restricted to the alar/basal boundary.
Specimen 6B': embryonic day 10.5; Foxa2tm1Khk/Foxa2tm1Khk, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant. Posterior Midbrain.
Structure Level Pattern Image Note
TS17: midbrain Present Regionally restricted 6B' In the posterior midbrain, conditional knockout expression was shifted ventrally so that basal progenitors maintained expression.
Specimen 6C: embryonic day 10.5; Foxa2tm1Khk/Foxa2tm1Khk (more )
Note: Control. Anterior Midbrain.
Structure Level Pattern Image Note
TS17: midbrain Present Regionally restricted 6C The ventral limit of expression was restricted to the alar/basal boundary.
Specimen 6C': embryonic day 10.5; Foxa2tm1Khk/Foxa2tm1Khk, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant. Anterior Midbrain.
Structure Level Pattern Image Note
TS17: midbrain Present Regionally restricted 6C' The normal pattern of expression was recovered in the anterior midbrain of the E10.5 conditional knockout.
Specimen 6D: embryonic day 12.5; Foxa1tm1Gsc/Foxa1tm1Gsc, Foxa2tm1Khk/Foxa2+ (more )
Note: Control; genotype either Foxa fl/fl; Foxa1 +/+ or Foxa2 fl/fl; Foxa1 +/-
Structure Level Pattern Image Note
TS20: midbrain Present Regionally restricted 6D The ventral limit of expression was restricted to the alar/basal boundary.
Specimen 6D': embryonic day 12.5; Foxa2tm1Khk/Foxa2tm1Khk, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: midbrain Present Regionally restricted 6D' The normal pattern of expression was detected in the midbrain of the E12.5 conditional knockout.
Specimen 6D'': embryonic day 12.5; Foxa1tm1Gsc/Foxa1tm1Gsc, Foxa2tm1Khk/Foxa2tm1Khk (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: midbrain Present Regionally restricted 6D'' In the double mutant conditional knockout, expression was restricted to the ventral midline of the midbrain.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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06/12/2024
MGI 6.13 		The Jackson Laboratory