About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:170258 Mavromatakis YE, et al., Foxa1 and Foxa2 positively and negatively regulate Shh signalling to specify ventral midbrain progenitor identity. Mech Dev. 2011 Jan-Feb;128(1-2):90-103
Assay type: RNA in situ
MGI Accession ID: MGI:6355444
Gene symbol: Gli1
Gene name: GLI-Kruppel family member GLI1
Results
Specimen 6E: embryonic day 9.5; Foxa2tm1Khk/Foxa2tm1Khk (more )
Note: Control.
Structure Level Pattern Image Note
TS15: future midbrain Present Regionally restricted 6E The ventral limit of expression was restricted to the alar/basal boundary.
Specimen 6E': embryonic day 9.5; Foxa2tm1Khk/Foxa2tm1Khk, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: future midbrain Present Regionally restricted 6E' In the conditional knockout the expression was shifted ventrally so that basal progenitors maintained expression.
Specimen 6F: embryonic day 10.5; Foxa2tm1Khk/Foxa2tm1Khk (more )
Note: Control. Posterior Midbrain.
Structure Level Pattern Image Note
TS17: midbrain Present Regionally restricted 6F The ventral limit of expression was restricted to the alar/basal boundary.
Specimen 6F': embryonic day 10.5; Foxa2tm1Khk/Foxa2tm1Khk, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant. Posterior Midbrain.
Structure Level Pattern Image Note
TS17: midbrain Present Regionally restricted 6F' In the posterior midbrain, conditional knockout expression was shifted ventrally so that basal progenitors maintained expression.
Specimen 6G: embryonic day 10.5; Foxa2tm1Khk/Foxa2tm1Khk (more )
Note: Control. Anterior Midbrain.
Structure Level Pattern Image Note
TS17: midbrain Present Regionally restricted 6G The ventral limit of expression was restricted to the alar/basal boundary.
Specimen 6G': embryonic day 10.5; Foxa2tm1Khk/Foxa2tm1Khk, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant. Anterior Midbrain.
Structure Level Pattern Image Note
TS17: midbrain Present Regionally restricted 6G' The normal pattern of expression was recovered in the anterior midbrain of the E10.5 conditional knockout.
Specimen 6H: embryonic day 12.5; Foxa1tm1Gsc/Foxa1tm1Gsc, Foxa2tm1Khk/Foxa2+ (more )
Note: Control; genotype either Foxa fl/fl; Foxa1 +/+ or Foxa2 fl/fl; Foxa1 +/-
Structure Level Pattern Image Note
TS20: midbrain Present Regionally restricted 6H The ventral limit of expression was restricted to the alar/basal boundary.
Specimen 6H': embryonic day 12.5; Foxa2tm1Khk/Foxa2tm1Khk, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: midbrain Present Regionally restricted 6H' The normal pattern of expression was detected in the midbrain of the E12.5 conditional knockout.
Specimen 6H'': embryonic day 12.5; Foxa1tm1Gsc/Foxa1tm1Gsc, Foxa2tm1Khk/Foxa2tm1Khk (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: midbrain Present Regionally restricted 6H'' In the double mutant conditional knockout, expression was restricted to the ventral midline of the midbrain.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory