About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:170258 Mavromatakis YE, et al., Foxa1 and Foxa2 positively and negatively regulate Shh signalling to specify ventral midbrain progenitor identity. Mech Dev. 2011 Jan-Feb;128(1-2):90-103
Assay type: RNA in situ
MGI Accession ID: MGI:6355446
Gene symbol: Gli3
Gene name: GLI-Kruppel family member GLI3
Probe: pGli-3a
Results
Specimen 6M: embryonic day 9.5; Foxa2tm1Khk/Foxa2tm1Khk (more )
Note: Control.
Structure Level Pattern Image Note
TS15: future midbrain Present 6M
Specimen 6M': embryonic day 9.5; Foxa2tm1Khk/Foxa2tm1Khk, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: future midbrain Present 6M' Expression appeared normal in the conditional knockout embryo.
Specimen 6N: embryonic day 10.5; Foxa2tm1Khk/Foxa2tm1Khk (more )
Note: Control. Posterior Midbrain.
Structure Level Pattern Image Note
TS17: midbrain Present 6N
Specimen 6N': embryonic day 10.5; Foxa2tm1Khk/Foxa2tm1Khk, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant. Posterior Midbrain.
Structure Level Pattern Image Note
TS17: midbrain Present 6N' Expression appeared normal in the conditional knockout embryo.
Specimen 6O: embryonic day 10.5; Foxa2tm1Khk/Foxa2tm1Khk (more )
Note: Control. Anterior Midbrain.
Structure Level Pattern Image Note
TS17: midbrain Present 6O
Specimen 6O': embryonic day 10.5; Foxa2tm1Khk/Foxa2tm1Khk, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant. Anterior Midbrain.
Structure Level Pattern Image Note
TS17: midbrain Present 6O' Expression appeared normal in the conditional knockout embryo.
Specimen 6P: embryonic day 12.5; Foxa1tm1Gsc/Foxa1tm1Gsc, Foxa2tm1Khk/Foxa2+ (more )
Note: Control; genotype either Foxa fl/fl; Foxa1 +/+ or Foxa2 fl/fl; Foxa1 +/-
Structure Level Pattern Image Note
TS20: midbrain Present 6P Expression in the wild type midbrain did not include the ventral midline.
Specimen 6P': embryonic day 12.5; Foxa2tm1Khk/Foxa2tm1Khk, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: midbrain Present 6P' Expression appeared normal in the conditional knockout embryo.
Specimen 6P'': embryonic day 12.5; Foxa1tm1Gsc/Foxa1tm1Gsc, Foxa2tm1Khk/Foxa2tm1Khk (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: midbrain Present Scattered 6P'' Expression was observed in scattered cells in the ventral midline of the double mutant.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory