About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:119144 Seo S, et al., The forkhead transcription factors, Foxc1 and Foxc2, are required for arterial specification and lymphatic sprouting during vascular development. Dev Biol. 2006 Jun 15;294(2):458-70
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6364012
Gene symbol: Prox1
Gene name: prospero homeobox 1
Antibody: Anti-Prox1 (PRB-238C; Poly19252)
Detection system: Cy3
Results
Specimen 3A: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: lymphatic system Present Regionally restricted 3A Expression in lymphatic endothelial cells sprouting from cardinal vein.
Specimen 3B: embryonic day 10.5; Foxc1tm1Blh/Foxc1+, Foxc2tm1Blh/Foxc2tm1Blh (more )
Structure Level Pattern Image Note
TS17: lymphatic system Weak Regionally restricted 3B Reduced number of expressing cells compared to wild type.
Specimen 3C: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: lymph sac Present 3C
TS19: lymphatic system Present Regionally restricted 3C Expression in sprouting lymphatic endothelial cells.
Specimen 3D: embryonic day 11.5; Foxc1tm1Blh/Foxc1+, Foxc2tm1Blh/Foxc2tm1Blh (more )
Structure Level Pattern Image Note
TS19: lymph sac Present Regionally restricted 3D Authors report abnormal formation of lymph sacs.
TS19: lymphatic system Weak Regionally restricted 3D Reduced sprouting of lymphatic endothelial cells.
Specimen S2B/C: embryonic day 10.5 (more )
Note: Double labeled: red - Prox1; green - BrdU.
Structure Level Pattern Image Note
TS17: lymphatic system Present Regionally restricted S2C , S2B Expression in lymphatic endothelial cells.
Specimen S2E/F: embryonic day 10.5; Foxc1tm1Blh/Foxc1+, Foxc2tm1Blh/Foxc2tm1Blh (more )
Note: Double labeled: red - Prox1; green - BrdU.
Structure Level Pattern Image Note
TS17: lymphatic system Present Regionally restricted S2F , S2E Expression in lymphatic endothelial cells.
Specimen S2H/I: embryonic day 11.5 (more )
Note: Double labeled: red - Prox1; green - BrdU.
Structure Level Pattern Image Note
TS19: lymphatic system Present Regionally restricted S2I , S2H Expression in lymphatic endothelial cells.
Specimen S2K/L: embryonic day 11.5; Foxc1tm1Blh/Foxc1+, Foxc2tm1Blh/Foxc2tm1Blh (more )
Note: Double labeled: red - Prox1; green - BrdU.
Structure Level Pattern Image Note
TS19: lymphatic system Present Regionally restricted S2L , S2K
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory