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Gene Expression Data
Assay Details
Assay
Reference: J:228706 Chandramouli A, et al., Ltbp1L is focally induced in embryonic mammary mesenchyme, demarcates the ductal luminal lineage and is upregulated during involution. Breast Cancer Res. 2013;15(6):R111
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:6369618
Gene symbol: Ltbp1
Gene name: latent transforming growth factor beta binding protein 1
Reporter: lacZ
Direct Detection
Results
Specimen 2A: embryonic day 10.5; Ltbp1tm1Vlcg/Ltbp1+ (more )
Structure Level Pattern Image Note
TS17: visceral organ system Present 2A
TS17: trunk Weak Regionally restricted 2A Expression is at the dorsal border of the mammary line overlying the somitic tips.
Specimen 2B: embryonic day 10.5; Ltbp1tm1Vlcg/Ltbp1+ (more )
Note: Vibratome section.
Structure Level Pattern Image Note
TS17: visceral organ system Present 2B
Specimen 2C: embryonic day 12.0-12.5; Ltbp1tm1Vlcg/Ltbp1+ (more )
Structure Level Pattern Image Note
TS20: trunk mesenchyme Present Regionally restricted 2C Expression is in a streak along the forelimb axilla and surrounding placodes 1 to 3.
Specimen 2D: embryonic day 12.0-12.5; Ltbp1tm1Vlcg/Ltbp1+ (more )
Structure Level Pattern Image Note
TS20: trunk mesenchyme Present Regionally restricted 2D Expression is in a gradient in the mesenchyme oriented towards mammary gland 1.
Specimen 3A: embryonic day 14.5; Ltbp1tm1Vlcg/Ltbp1+ (more )
Structure Level Pattern Image Note
TS22: trunk mesenchyme Strong Regionally restricted 3A Expression is in a halo surrounding all mammary buds.
TS22: mammary mesenchyme Strong 3A
Specimen 3B: embryonic day 14.5; Ltbp1tm1Vlcg/Ltbp1+ (more )
Structure Level Pattern Image Note
TS22: trunk mesenchyme Weak Regionally restricted 3B Expression is in a halo surrounding all mammary buds.
TS22: mammary mesenchyme Weak 3B
Specimen 3C: embryonic day 14.5; Ltbp1tm1Vlcg/Ltbp1+ (more )
Note: Double labeled: blue - Ltbp1 reporter; brown - Trp63 (assay MGI:6369720).
Structure Level Pattern Image Note
TS22: mammary mesenchyme Strong 3C
Specimen 3D: embryonic day 14.5; Ltbp1tm1Vlcg/Ltbp1+ (more )
Note: Double labeled: blue - Ltbp1 reporter; brown - Krt14 (assay MGI:6369721).
Structure Level Pattern Image Note
TS22: mammary mesenchyme Strong 3D
Specimen 3E: embryonic day 14.5; Ltbp1tm1Vlcg/Ltbp1+ (more )
Note: Double labeled: blue - Ltbp1 reporter; brown - Esr1 (assay MGI:6369722).
Structure Level Pattern Image Note
TS22: mammary mesenchyme Strong 3E
Specimen 3F: embryonic day 14.5; Ltbp1tm1Vlcg/Ltbp1+ (more )
Note: Double labeled: blue - Ltbp1 reporter; brown - Ar (assay MGI:6369723).
Structure Level Pattern Image Note
TS22: mammary mesenchyme Strong 3F
Specimen 3G: embryonic day 14.5; Ltbp1tm1Vlcg/Ltbp1+ (more )
Note: Double labeled: blue - Ltbp1 reporter; brown - Lef1 (assay MGI:6369724).
Structure Level Pattern Image Note
TS22: mammary mesenchyme Strong 3G
Specimen 4A: embryonic day 16.5; Ltbp1tm1Vlcg/Ltbp1+ (more )
Structure Level Pattern Image Note
TS24: hair follicle Strong 4A
TS24: mammary gland primordium Strong 4A
Specimen 4B: embryonic day 16.5; Ltbp1tm1Vlcg/Ltbp1+ (more )
Structure Level Pattern Image Note
TS24: mammary mesenchyme Strong 4B
TS24: mammary gland primordium epithelium Absent 4B
Specimen 4C: postnatal day 1; Ltbp1tm1Vlcg/Ltbp1+ (more )
Structure Level Pattern Image Note
TS27: mammary gland smooth muscle Present Regionally restricted 4C Expression is in smooth muscle cells at the base of the nipple shield extending radially into the developing areola.
Specimen 4D: postnatal day 1; Ltbp1tm1Vlcg/Ltbp1+ (more )
Structure Level Pattern Image Note
TS27: mammary gland smooth muscle Present Regionally restricted 4D Expression is in smooth-muscle cells at the base of the nipple shield extending radially into the developing areola.
Specimen 5A: postnatal adult; Ltbp1tm1Vlcg/Ltbp1+ (more )
Note: Virgin mouse.
Structure Level Pattern Image Note
TS28: mammary gland smooth muscle Strong Regionally restricted 5A Expression is in bands of smooth-muscle cells at the base of the nipple underlying the areola in the region of the nipple sphincter.
TS28: nipple Present Regionally restricted 5A Absent in nipple stromal cells at most developmental ages (shown) and is present during mid-pregnancy.
Specimen 5B: postnatal adult; Ltbp1tm1Vlcg/Ltbp1+ (more )
Note: Pregnancy day 14.5.
Structure Level Pattern Image Note
TS28: mammary gland smooth muscle Strong Regionally restricted 5B Expression is in bands of smooth-muscle cells at the base of the nipple underlying the areola in the region of the nipple sphincter.
Specimen 5B': postnatal adult; Ltbp1tm1Vlcg/Ltbp1+ (more )
Note: Pregnancy day 14.5.
Structure Level Pattern Image Note
TS28: mammary gland smooth muscle Present Regionally restricted 5B' Expression is in bands of smooth-muscle cells at the base of the nipple underlying the areola in the region of the nipple sphincter.
Specimen 5C: postnatal adult; Ltbp1tm1Vlcg/Ltbp1+ (more )
Note: Pregnancy day 13.5. Double labeled: blue - Ltbp1 reporter; brown - Acta2 (assay MGI:6369727).
Structure Level Pattern Image Note
TS28: mammary gland smooth muscle Strong Regionally restricted 5C Expression is in bands of smooth-muscle cells at the base of the nipple underlying the areola in the region of the nipple sphincter.
Specimen 5C': postnatal adult; Ltbp1tm1Vlcg/Ltbp1+ (more )
Note: Pregnancy day 13.5.
Structure Level Pattern Image Note
TS28: mammary gland smooth muscle Strong Regionally restricted 5C' Expression is in bands of smooth-muscle cells at the base of the nipple underlying the areola in the region of the nipple sphincter.
Specimen 5D: postnatal adult; Ltbp1tm1Vlcg/Ltbp1+ (more )
Note: Double labeled: blue - Ltbp1; purple - elastin fibers.
Structure Level Pattern Image Note
TS28: mammary gland smooth muscle Present Regionally restricted 5D Expression is in bands of smooth-muscle cells at the base of the nipple underlying the areola in the region of the nipple sphincter.
Specimen 5E: postnatal adult; Ltbp1tm1Vlcg/Ltbp1+ (more )
Note: Pregnancy day 13.5.
Structure Level Pattern Image Note
TS28: mammary gland smooth muscle Present Regionally restricted 5E Expression is in bands of smooth-muscle cells at the base of the nipple underlying the areola in the region of the nipple sphincter.
TS28: nipple Present Regionally restricted 5E Absent in nipple stromal cells at most developmental ages and is present during mid-pregnancy (shown).
Specimen 5F: postnatal adult; Ltbp1tm1Vlcg/Ltbp1+ (more )
Note: Pregnancy day 15.5. Double labeled: blue - Ltbp1 reporter; brown - Vim (assay MGI:6369731).
Structure Level Pattern Image Note
TS28: nipple Present Regionally restricted 5F , 5F' Expression is in stromal cells underlying the nipple germinative epithelium just prior to clefting.
Specimen 5G: postnatal adult; Ltbp1tm1Vlcg/Ltbp1+ (more )
Note: Pregnancy day 16.5.
Structure Level Pattern Image Note
TS28: mammary gland duct Present Regionally restricted 5G Expression is absent in the region of the lactiferous duct within the nipple and is present as the duct enters the fat pad at the base of the nipple.
TS28: nipple Present Regionally restricted 5G Absent in nipple stromal cells at most developmental ages (shown) and is present during mid-pregnancy.
Specimen 5H: postnatal adult; Ltbp1tm1Vlcg/Ltbp1+ (more )
Note: Involution stage.
Structure Level Pattern Image Note
TS28: mammary gland duct Present Regionally restricted 5H Expression is absent in the region of the lactiferous duct within the nipple and is present as the duct enters the fat pad at the base of the nipple.
TS28: nipple Present Regionally restricted 5H Absent in nipple stromal cells at most developmental ages (shown) and is present during mid-pregnancy.
Specimen 6A: embryonic day 17.5; Ltbp1tm1Vlcg/Ltbp1+ (more )
Structure Level Pattern Image Note
TS25: mammary mesenchyme Present 6A
TS25: mammary sprout Present 6A
Specimen 6B: embryonic day 17.5; Ltbp1tm1Vlcg/Ltbp1+ (more )
Structure Level Pattern Image Note
TS25: mammary mesenchyme Present 6B
TS25: mammary sprout Present 6B
TS25: mammary gland primordium epithelium Present Regionally restricted 6B Expression is in luminal cells in the microlumen.
Specimen 6C: postnatal day 1; Ltbp1tm1Vlcg/Ltbp1+ (more )
Structure Level Pattern Image Note
TS27: mammary gland duct Present 6C
TS27: mammary gland smooth muscle Present Regionally restricted 6C Expression is in the developing smooth muscle cells of the nipple areola.
Specimen 6D: postnatal day 1; Ltbp1tm1Vlcg/Ltbp1+ (more )
Structure Level Pattern Image Note
TS27: mammary gland duct Present Regionally restricted 6D Expression is in luminal cells in the microlumen and is absent in the stratified epithelium of the lactiferous duct within the nipple.
TS27: mammary gland smooth muscle Present Regionally restricted 6D Expression is in the developing smooth muscle cells of the nipple areola.
Specimen 6E: embryonic day 18.5; Ltbp1tm1Vlcg/Ltbp1+ (more )
Structure Level Pattern Image Note
TS26: mammary sprout Present Regionally restricted 6E Expression is absent from the bulbous multilayered tips.
Specimen 7C: postnatal week 5; Ltbp1tm1Vlcg/Ltbp1+ (more )
Note: Virgin mouse.
Structure Level Pattern Image Note
TS28: mammary duct terminal end bud Present 7C Expression is punctate in a subset of luminal cells in the internal portion of the terminal end bud and is surrounded by non-expressing cap and body cell layers.
Specimen 7D: postnatal week 5; Ltbp1tm1Vlcg/Ltbp1+ (more )
Note: Virgin mouse.
Structure Level Pattern Image Note
TS28: mammary duct terminal end bud Present 7D Expression is in a subset of luminal cells in the internal portion of the terminal end bud and is surrounded by non-expressing cap and body cell layers.
Specimen 8A: postnatal adult; Ltbp1tm1Vlcg/Ltbp1+ (more )
Structure Level Pattern Image Note
TS28: mammary duct terminal end bud Present Regionally restricted 8A Expression is in luminal cells.
Specimen 8B: postnatal adult; Ltbp1tm1Vlcg/Ltbp1+ (more )
Structure Level Pattern Image Note
TS28: mammary duct terminal end bud Present Regionally restricted 8B Expression is in luminal cells.
Specimen 8B inset: postnatal adult; Ltbp1tm1Vlcg/Ltbp1+ (more )
Note: Double labeled: blue - Ltbp1 reporter; brown - Trp63 (assay MGI:6369720).
Structure Level Pattern Image Note
TS28: mammary duct terminal end bud Present Regionally restricted 8B inset Expression is in luminal cells.
Specimen 9A: postnatal adult; Ltbp1tm1Vlcg/Ltbp1+ (more )
Note: Pregnancy day 13.5.
Structure Level Pattern Image Note
TS28: mammary gland duct Present 9A Expression is in ducts and side branches at all stages of pregnancy.
TS28: mammary gland alveolus Absent 9A
Specimen 9B: postnatal adult; Ltbp1tm1Vlcg/Ltbp1+ (more )
Note: Pregnancy day 13.5.
Structure Level Pattern Image Note
TS28: mammary gland duct Present 9B Expression is in ducts and side branches at all stages of pregnancy.
TS28: mammary gland alveolus Absent 9B
Specimen 9C: postnatal adult; Ltbp1tm1Vlcg/Ltbp1+ (more )
Note: Pregnancy day 14.5.
Structure Level Pattern Image Note
TS28: mammary gland duct Present 9C Expression is in ducts and side branches at all stages of pregnancy.
TS28: mammary gland alveolus Absent 9C
Specimen 9D: postnatal adult; Ltbp1tm1Vlcg/Ltbp1+ (more )
Note: Pregnancy day 14.5.
Structure Level Pattern Image Note
TS28: mammary gland duct Present 9D Expression is in ducts and side branches at all stages of pregnancy.
TS28: mammary gland alveolus Absent 9D
Specimen 9E: postnatal adult; Ltbp1tm1Vlcg/Ltbp1+ (more )
Note: Pregnancy day 16.5.
Structure Level Pattern Image Note
TS28: mammary gland duct Present 9E Expression is in ducts and side branches at all stages of pregnancy.
TS28: mammary gland alveolus Absent 9E
Specimen 9F: postnatal adult; Ltbp1tm1Vlcg/Ltbp1+ (more )
Note: Pregnancy day 16.5.
Structure Level Pattern Image Note
TS28: mammary gland duct Present 9F Expression is in ducts and side branches at all stages of pregnancy.
TS28: mammary gland alveolus Absent 9F
Specimen 10A: postnatal adult; Ltbp1tm1Vlcg/Ltbp1+ (more )
Note: Lactating mouse.
Structure Level Pattern Image Note
TS28: mammary gland alveolus Absent 10A
TS28: mammary gland duct Absent 10A
Specimen 10B: postnatal adult; Ltbp1tm1Vlcg/Ltbp1+ (more )
Note: Lactating mouse.
Structure Level Pattern Image Note
TS28: mammary gland alveolus Absent 10B
TS28: mammary gland duct Absent 10B
Specimen 10C: postnatal adult; Ltbp1tm1Vlcg/Ltbp1+ (more )
Note: Involuting glands removed 24 hours after pup weaning.
Structure Level Pattern Image Note
TS28: mammary gland duct Present Regionally restricted 10C Expression is along the main ducts and distended primary side branches.
Specimen 10D: postnatal adult; Ltbp1tm1Vlcg/Ltbp1+ (more )
Note: Involuting glands removed 24 hours after pup weaning.
Structure Level Pattern Image Note
TS28: mammary gland duct Present Regionally restricted 10D Expression is along the main ducts and distended primary side branches.
TS28: mammary gland alveolus Absent 10D
Specimen 10E: postnatal adult; Ltbp1tm1Vlcg/Ltbp1+ (more )
Note: Involuting glands removed 72 hours after pup weaning.
Structure Level Pattern Image Note
TS28: mammary gland epithelium Strong 10E
Specimen 10F: postnatal adult; Ltbp1tm1Vlcg/Ltbp1+ (more )
Note: Involuting glands removed 72 hours after pup weaning.
Structure Level Pattern Image Note
TS28: mammary gland epithelium Strong 10F
Specimen 10H: postnatal adult; Ltbp1tm1Vlcg/Ltbp1+ (more )
Note: Involution day 21.
Structure Level Pattern Image Note
TS28: mammary gland duct Present 10H
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory