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Gene Expression Data
Assay Details
Assay
Reference: J:136041 Gage PJ, et al., The canonical Wnt signaling antagonist DKK2 is an essential effector of PITX2 function during normal eye development. Dev Biol. 2008 May 1;317(1):310-24
Assay type: RNA in situ
MGI Accession ID: MGI:6385652
Gene symbol: Axin2
Gene name: axin 2
Probe: Axin2 probe17
Probe preparation: labelled with digoxigenin
Results
Specimen 1C i: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: eye epithelium Ambiguous 1C i
Specimen 1C ii: embryonic day 15.5; Dkk2tm1Dwu/Dkk2tm1Dwu (more )
Structure Level Pattern Image Note
TS23: conjunctival sac Strong Regionally restricted 1C ii Expression robustly enhanced in conjunctiva, limbus and cornea compared to wild type.
TS23: eye epithelium Very strong Regionally restricted 1C ii Strongest expression in basal cells of surface ectoderm as well as in adjacent mesenchyme.
TS23: eye mesenchyme Very strong Regionally restricted 1C ii Strongest expression in basal cells of surface ectoderm as well as in adjacent mesenchyme.
TS23: cornea epithelium Strong Regionally restricted 1C ii Expression highly up-regulated in ocular surface ectoderm and underlying mesenchyme within iridocorneal angle.
TS23: cornea stroma Strong Regionally restricted 1C ii Expression highly up-regulated in ocular surface ectoderm and underlying mesenchyme within iridocorneal angle.
Specimen 1C iii: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: eye epithelium Ambiguous 1C iii
Specimen 1C iv: embryonic day 15.5; Dkk2tm1Dwu/Dkk2tm1Dwu (more )
Structure Level Pattern Image Note
TS23: conjunctival sac Strong Regionally restricted 1C iv Expression robustly enhanced in conjunctiva, limbus and cornea compared to wild type.
TS23: eye epithelium Very strong Regionally restricted 1C iv Strongest expression in basal cells of surface ectoderm as well as in adjacent mesenchyme.
TS23: eye mesenchyme Very strong Regionally restricted 1C iv Strongest expression in basal cells of surface ectoderm as well as in adjacent mesenchyme.
TS23: cornea epithelium Strong Regionally restricted 1C iv Expression highly up-regulated in ocular surface ectoderm and underlying mesenchyme within central cornea.
TS23: cornea stroma Strong Regionally restricted 1C iv Expression elevated in corneal stromal cells more distant from surface ectoderm.
Specimen 1D i: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: eyelid epithelium Present 1D i Expression within surface ectoderm of eyelids and conjuctiva.
TS21: eye epithelium Present Regionally restricted 1D i Expression within surface ectoderm of eyelids and conjuctiva.
TS21: cornea epithelium Absent 1D i Expression ceases at border between conjunctival and corneal ectoderm. Expression excluded from presumptive limbal and corneal epithelium.
TS21: cornea stroma Present 1D i Expression in underlying mesenchyme of presumptive cornea and eyelid.
TS21: eyelid mesenchyme Present 1D i Expression in underlying mesenchyme of presumptive cornea and eyelid.
TS21: eye mesenchyme Present Regionally restricted 1D i
Specimen 1D ii: embryonic day 13.5; Pitx2tm2Sac/Pitx2tm2Sac (more )
Structure Level Pattern Image Note
TS21: eye surface region Present Widespread 1D ii Expressione extends throughout ocular surface ectoderm.
TS21: cornea epithelium Present 1D ii
TS21: lens Present Regionally restricted 1D ii Expression in persistent lens stalk
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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06/12/2024
MGI 6.13 		The Jackson Laboratory