Results
|
Specimen
2A:
embryonic day 9.5; Sox8tm1Weg/Sox8 +
(more )
Specimen
2A:
(close )
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
Mutant Allele(s):
|
Sox8tm1Weg/Sox8+
|
Age:
|
embryonic day 9.5
|
Sex:
|
Not Specified
|
Type:
|
whole mount
|
Fixation:
|
Paraformaldehyde
|
Specimen
2A insert:
embryonic day 9.5; Sox8tm1Weg/Sox8 +
(more )
Specimen
2A insert:
(close )
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
Mutant Allele(s):
|
Sox8tm1Weg/Sox8+
|
Age:
|
embryonic day 9.5
|
Sex:
|
Not Specified
|
Type:
|
whole mount
|
Fixation:
|
Paraformaldehyde
|
Specimen
2B:
embryonic day 10.5; Sox8tm1Weg/Sox8 +
(more )
Specimen
2B:
(close )
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
Mutant Allele(s):
|
Sox8tm1Weg/Sox8+
|
Age:
|
embryonic day 10.5
|
Sex:
|
Not Specified
|
Type:
|
whole mount
|
Fixation:
|
Paraformaldehyde
|
Specimen
2C:
embryonic day 11.5; Sox8tm1Weg/Sox8 +
(more )
Specimen
2C:
(close )
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
Mutant Allele(s):
|
Sox8tm1Weg/Sox8+
|
Age:
|
embryonic day 11.5
|
Sex:
|
Not Specified
|
Type:
|
whole mount
|
Fixation:
|
Paraformaldehyde
|
Structure |
Level |
Pattern |
Image |
Note |
TS19: head mesenchyme |
Present |
Regionally restricted |
2C
|
Expression in facial mesenchyme recedes to ventro-rostral region including nasal invagination.
|
TS19: nasal pit |
Present |
|
2C
|
Expression in facial mesenchyme recedes to ventro-rostral region including nasal invagination.
|
TS19: hindbrain |
Present |
Regionally restricted |
2C
|
Expression in pontine region of hindbrain.
|
TS19: cranial ganglion |
Strong |
|
2C
|
|
TS19: dorsal root ganglion |
Strong |
|
2C
|
|
TS19: myotome |
Present |
|
2C
|
|
TS19: limb bud |
Present |
Regionally restricted |
2C
|
Expression restricted to base of limb buds.
|
TS19: heart |
Ambiguous |
Regionally restricted |
2C
|
Expression consistently absent in heart, liver and adipose tissue.
|
TS19: liver |
Ambiguous |
Regionally restricted |
2C
|
Expression consistently absent in heart, liver and adipose tissue.
|
Specimen
2E:
embryonic day 14.5; Sox8tm1Weg/Sox8 +
(more )
Specimen
2E:
(close )
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
Mutant Allele(s):
|
Sox8tm1Weg/Sox8+
|
Age:
|
embryonic day 14.5
|
Sex:
|
Not Specified
|
Type:
|
section
|
Fixation:
|
Paraformaldehyde
|
Embedding:
|
Agarose
|
Specimen
2F:
embryonic day 16.5; Sox8tm1Weg/Sox8 +
(more )
Specimen
2F:
(close )
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
Mutant Allele(s):
|
Sox8tm1Weg/Sox8+
|
Age:
|
embryonic day 16.5
|
Sex:
|
Not Specified
|
Type:
|
section
|
Fixation:
|
Paraformaldehyde
|
Embedding:
|
Agarose
|
Structure |
Level |
Pattern |
Image |
Note |
TS24: corpus striatum |
Strong |
Widespread |
2F
|
Prominent expression in all layers of striatum.
|
TS24: brain ventricular layer |
Strong |
|
2F
|
|
TS24: cerebellum |
Present |
|
2F
|
|
TS24: diaphragm |
Present |
|
2F
|
|
TS24: intercostal muscle |
Present |
|
2F
|
|
TS24: hyoid |
Strong |
|
2F
|
Strong expression in cartilage and endochondral structures, e.g. cartilage of nose and ear, thyroid and hyoid cartilage, and cartilage of ribs, vertibrae and limbs.
|
TS24: limb cartilage condensation |
Strong |
|
2F
|
Strong expression in cartilage and endochondral structures, e.g. cartilage of nose and ear, thyroid and hyoid cartilage, and cartilage of ribs, vertibrae and limbs.
|
TS24: rib cartilage |
Strong |
|
2F
|
Strong expression in cartilage and endochondral structures, e.g. cartilage of nose and ear, thyroid and hyoid cartilage, and cartilage of ribs, vertibrae and limbs.
|
TS24: sensory organ cartilage |
Strong |
|
2F
|
Strong expression in cartilage and endochondral structures, e.g. cartilage of nose and ear, thyroid and hyoid cartilage, and cartilage of ribs, vertibrae and limbs.
|
TS24: thyroid cartilage |
Strong |
|
2F
|
Strong expression in cartilage and endochondral structures, e.g. cartilage of nose and ear, thyroid and hyoid cartilage, and cartilage of ribs, vertibrae and limbs.
|
TS24: vertebral cartilage condensation |
Strong |
|
2F
|
Strong expression in cartilage and endochondral structures, e.g. cartilage of nose and ear, thyroid and hyoid cartilage, and cartilage of ribs, vertibrae and limbs.
|
TS24: metanephros |
Present |
Regionally restricted |
2F
|
Expression in kidney restricted to glomeruli and proximal tubules.
|
Specimen
2G:
(close )
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
Mutant Allele(s):
|
Sox8tm1Weg/Sox8tm1Weg
|
Age:
|
embryonic day 12.5
|
Sex:
|
Not Specified
|
Type:
|
section
|
Fixation:
|
Paraformaldehyde
|
Embedding:
|
Agarose
|
Structure |
Level |
Pattern |
Image |
Note |
TS20: ganglionic eminence |
Present |
Regionally restricted |
2G
|
In ganglionic eminence, expression in ventricular, subventricular and mantle zones.
|
TS20: medulla oblongata |
Present |
Regionally restricted |
2G
|
Expression in some nuclei of pons and medulla oblongata.
|
TS20: pons |
Present |
Regionally restricted |
2G
|
Expression in some nuclei of pons and medulla oblongata.
|
TS20: metanephros |
Present |
Regionally restricted |
2G
|
From E14.5, expression in kidney restricted to glomeruli and proximal tubules.
|
Specimen
2H:
(close )
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
Mutant Allele(s):
|
Sox8tm1Weg/Sox8tm1Weg
|
Age:
|
embryonic day 14.5
|
Sex:
|
Not Specified
|
Type:
|
section
|
Fixation:
|
Paraformaldehyde
|
Embedding:
|
Agarose
|
Specimen
2I:
(close )
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
Mutant Allele(s):
|
Sox8tm1Weg/Sox8tm1Weg
|
Age:
|
embryonic day 16.5
|
Sex:
|
Not Specified
|
Type:
|
section
|
Fixation:
|
Paraformaldehyde
|
Embedding:
|
Agarose
|
Structure |
Level |
Pattern |
Image |
Note |
TS24: corpus striatum |
Present |
Widespread |
2I
|
Prominent expression in all layers of striatum.
|
TS24: diaphragm |
Present |
|
2I
|
|
TS24: intercostal muscle |
Present |
|
2I
|
|
TS24: hyoid |
Strong |
|
2I
|
Strong expression in cartilage and endochondral structures, e.g. cartilage of nose and ear, thyroid and hyoid cartilage, and cartilage of ribs, vertibrae and limbs.
|
TS24: limb cartilage condensation |
Strong |
|
2I
|
Strong expression in cartilage and endochondral structures, e.g. cartilage of nose and ear, thyroid and hyoid cartilage, and cartilage of ribs, vertibrae and limbs.
|
TS24: rib cartilage |
Strong |
|
2I
|
Strong expression in cartilage and endochondral structures, e.g. cartilage of nose and ear, thyroid and hyoid cartilage, and cartilage of ribs, vertibrae and limbs.
|
TS24: sensory organ cartilage |
Strong |
|
2I
|
Strong expression in cartilage and endochondral structures, e.g. cartilage of nose and ear, thyroid and hyoid cartilage, and cartilage of ribs, vertibrae and limbs.
|
TS24: thyroid cartilage |
Strong |
|
2I
|
Strong expression in cartilage and endochondral structures, e.g. cartilage of nose and ear, thyroid and hyoid cartilage, and cartilage of ribs, vertibrae and limbs.
|
TS24: vertebral cartilage condensation |
Strong |
|
2I
|
Strong expression in cartilage and endochondral structures, e.g. cartilage of nose and ear, thyroid and hyoid cartilage, and cartilage of ribs, vertibrae and limbs.
|
TS24: metanephros |
Present |
Regionally restricted |
2I
|
Expression in kidney restricted to glomeruli and prximal tubules.
|
Specimen
3A:
(close )
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
Mutant Allele(s):
|
Sox8tm1Weg/Sox8tm1Weg
|
Age:
|
embryonic day 15.5
|
Sex:
|
Not Specified
|
Type:
|
section
|
Fixation:
|
Paraformaldehyde
|
Embedding:
|
Agarose
|
Structure |
Level |
Pattern |
Image |
Note |
TS23: head |
Present |
Regionally restricted |
3A
|
Expression in head including nasal epithelium and innervation.
|
TS23: olfactory epithelium |
Present |
Regionally restricted |
3A
|
|
Specimen
3B:
(close )
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
Mutant Allele(s):
|
Sox8tm1Weg/Sox8tm1Weg
|
Age:
|
embryonic day 15.5
|
Sex:
|
Not Specified
|
Type:
|
section
|
Fixation:
|
Paraformaldehyde
|
Embedding:
|
Agarose
|
Specimen
3C:
(close )
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
Mutant Allele(s):
|
Sox8tm1Weg/Sox8tm1Weg
|
Age:
|
embryonic day 15.5
|
Sex:
|
Not Specified
|
Type:
|
section
|
Fixation:
|
Paraformaldehyde
|
Embedding:
|
Agarose
|
Specimen
3D:
(close )
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
Mutant Allele(s):
|
Sox8tm1Weg/Sox8tm1Weg
|
Age:
|
embryonic day 15.5
|
Sex:
|
Not Specified
|
Type:
|
section
|
Fixation:
|
Paraformaldehyde
|
Embedding:
|
Agarose
|
Structure |
Level |
Pattern |
Image |
Note |
TS23: trigeminal nerve |
Present |
|
3D
|
Residual expression detectable in trigeminal nerve.
|
Specimen
3E:
(close )
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
Mutant Allele(s):
|
Sox8tm1Weg/Sox8tm1Weg
|
Age:
|
embryonic day 16.5
|
Sex:
|
Not Specified
|
Type:
|
section
|
Fixation:
|
Paraformaldehyde
|
Embedding:
|
Agarose
|
Specimen
3F:
(close )
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
Mutant Allele(s):
|
Sox8tm1Weg/Sox8tm1Weg
|
Age:
|
embryonic day 16.5
|
Sex:
|
Not Specified
|
Type:
|
section
|
Fixation:
|
Paraformaldehyde
|
Embedding:
|
Agarose
|
Specimen
4B:
postnatal newborn; Sox8tm1Weg/Sox8 +
(more )
Specimen
4B:
(close )
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
Mutant Allele(s):
|
Sox8tm1Weg/Sox8+
|
Age:
|
postnatal newborn
|
Sex:
|
Not Specified
|
Type:
|
section
|
Fixation:
|
Paraformaldehyde
|
Embedding:
|
Agarose
|
Structure |
Level |
Pattern |
Image |
Note |
TS27: corpus striatum |
Present |
Regionally restricted |
4B
|
Expression in neurons of striatum.
|
TS27: hindbrain |
Weak |
Regionally restricted |
4B
|
Expression in hindbrain nuclei, which gradually reduced.
|
TS27: brain ventricular layer |
Present |
Widespread |
4B
|
Expression in ventricular zone spread throughout brain.
|
Specimen
4C:
(close )
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
Mutant Allele(s):
|
Sox8tm1Weg/Sox8tm1Weg
|
Age:
|
postnatal newborn
|
Sex:
|
Not Specified
|
Type:
|
section
|
Fixation:
|
Paraformaldehyde
|
Embedding:
|
Agarose
|
Structure |
Level |
Pattern |
Image |
Note |
TS27: corpus striatum |
Present |
Regionally restricted |
4C
|
Expression in neurons of striatum.
|
TS27: hindbrain |
Weak |
Regionally restricted |
4C
|
Expression in hindbrain nuclei, which gradually reduced.
|
TS27: brain ventricular layer |
Present |
Widespread |
4C
|
Expression in ventricular zone spread throughout brain.
|
Specimen
4E:
postnatal month 4; Sox8tm1Weg/Sox8 +
(more )
Specimen
4E:
(close )
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
Mutant Allele(s):
|
Sox8tm1Weg/Sox8+
|
Age:
|
postnatal month 4
|
Sex:
|
Not Specified
|
Type:
|
section
|
Fixation:
|
Paraformaldehyde
|
Embedding:
|
Agarose
|
Specimen
4F:
(close )
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
Mutant Allele(s):
|
Sox8tm1Weg/Sox8tm1Weg
|
Age:
|
postnatal month 4
|
Sex:
|
Not Specified
|
Type:
|
section
|
Fixation:
|
Paraformaldehyde
|
Embedding:
|
Agarose
|
Specimen
4H:
postnatal month 4; Sox8tm1Weg/Sox8 +
(more )
Specimen
4H:
(close )
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
Mutant Allele(s):
|
Sox8tm1Weg/Sox8+
|
Age:
|
postnatal month 4
|
Sex:
|
Not Specified
|
Type:
|
section
|
Fixation:
|
Paraformaldehyde
|
Embedding:
|
Agarose
|
Structure |
Level |
Pattern |
Image |
Note |
TS28: spinal cord |
Present |
Regionally restricted |
4H
|
Expression pattern in spinal cord most compatible with mixed glial expression.
|
Specimen
4I:
(close )
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
Mutant Allele(s):
|
Sox8tm1Weg/Sox8tm1Weg
|
Age:
|
postnatal month 4
|
Sex:
|
Not Specified
|
Type:
|
section
|
Fixation:
|
Paraformaldehyde
|
Embedding:
|
Agarose
|
Structure |
Level |
Pattern |
Image |
Note |
TS28: spinal cord |
Present |
Regionally restricted |
4I
|
Expression pattern in spinal cord most compatible with mixed glial expression.
|
Specimen
4J:
(close )
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
Mutant Allele(s):
|
Sox8tm1Weg/Sox8tm1Weg
|
Age:
|
postnatal adult
|
Sex:
|
Not Specified
|
Type:
|
section
|
Fixation:
|
Paraformaldehyde
|
Embedding:
|
Agarose
|
Structure |
Level |
Pattern |
Image |
Note |
TS28: corpus striatum |
Strong |
Regionally restricted |
4J
|
In adult striatum, strong expression in oligodendrocytes of fiber tracts and in isolated cells with astrocytic morphology.
|
Specimen
4K:
(close )
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
Mutant Allele(s):
|
Sox8tm1Weg/Sox8tm1Weg
|
Age:
|
postnatal adult
|
Sex:
|
Not Specified
|
Type:
|
section
|
Fixation:
|
Paraformaldehyde
|
Embedding:
|
Agarose
|
Specimen
4L:
(close )
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
Mutant Allele(s):
|
Sox8tm1Weg/Sox8tm1Weg
|
Age:
|
postnatal adult
|
Sex:
|
Not Specified
|
Type:
|
section
|
Fixation:
|
Paraformaldehyde
|
Embedding:
|
Agarose
|
Specimen
5A:
(close )
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
Mutant Allele(s):
|
Sox8tm1Weg/Sox8tm1Weg
|
Age:
|
embryonic day 16.5
|
Sex:
|
Not Specified
|
Type:
|
section
|
Fixation:
|
Paraformaldehyde
|
Embedding:
|
Agarose
|
Specimen
5B:
(close )
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
Mutant Allele(s):
|
Sox8tm1Weg/Sox8tm1Weg
|
Age:
|
postnatal adult
|
Sex:
|
Not Specified
|
Type:
|
section
|
Fixation:
|
Paraformaldehyde
|
Embedding:
|
Agarose
|
Structure |
Level |
Pattern |
Image |
Note |
TS28: metanephros |
Absent |
|
5B
|
No detectable expression in adult kidney.
|
Specimen
5C:
(close )
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
Mutant Allele(s):
|
Sox8tm1Weg/Sox8tm1Weg
|
Age:
|
postnatal adult
|
Sex:
|
Not Specified
|
Type:
|
section
|
Fixation:
|
Paraformaldehyde
|
Embedding:
|
Agarose
|
Specimen
5D:
(close )
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
Mutant Allele(s):
|
Sox8tm1Weg/Sox8tm1Weg
|
Age:
|
postnatal adult
|
Sex:
|
Male
|
Type:
|
section
|
Fixation:
|
Paraformaldehyde
|
Embedding:
|
Agarose
|
Structure |
Cell Type |
Level |
Pattern |
Image |
Note |
TS28: seminiferous tubule epithelium |
|
Present |
Regionally restricted |
5D
|
Expression restricted to interior lining of testicular tubules, localized to Sertoli cells and not to spermatogonia.
|
TS28: Sertoli cell |
Sertoli cell |
Present |
|
5D
|
Expression restricted to interior lining of testicular tubules, localized to Sertoli cells and not to spermatogonia.
|
TS28: spermatogonium |
|
Absent |
|
5D
|
Expression restricted to interior lining of testicular tubules, localized to Sertoli cells and not to spermatogonia.
|
Specimen
heterozygote not shown:
postnatal adult; Sox8tm1Weg/Sox8 +
(more )
Specimen
heterozygote not shown:
(close )
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
Mutant Allele(s):
|
Sox8tm1Weg/Sox8+
|
Age:
|
postnatal adult
|
Sex:
|
Not Specified
|
Type:
|
section
|
Fixation:
|
Paraformaldehyde
|
Embedding:
|
Agarose
|
Structure |
Level |
Pattern |
Image |
Note |
TS28: metanephros |
Absent |
|
|
Authors report no difference between heterozygous and homozygous mutant littermates.
|
TS28: adrenal medulla |
Present |
|
|
Authors report no difference between heterozygous and homozygous mutant littermates.
|
TS28: testis |
Present |
|
|
Authors report no difference between heterozygous and homozygous mutant littermates.
|
Specimen
1 week after birth not shown:
postnatal week 1; Sox8tm1Weg/Sox8 +
(more )
Specimen
1 week after birth not shown:
(close )
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
Mutant Allele(s):
|
Sox8tm1Weg/Sox8+
|
Age:
|
postnatal week 1
|
Sex:
|
Not Specified
|
Type:
|
section
|
Fixation:
|
Paraformaldehyde
|
Embedding:
|
Agarose
|
Structure |
Level |
Pattern |
Image |
Note |
TS28: skeletal muscle |
Strong |
Widespread |
|
Significant expression throughout skeletal muscle.
|
Specimen
2 weels after birth not shown:
postnatal week 2; Sox8tm1Weg/Sox8 +
(more )
Specimen
2 weels after birth not shown:
(close )
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
Mutant Allele(s):
|
Sox8tm1Weg/Sox8+
|
Age:
|
postnatal week 2
|
Sex:
|
Not Specified
|
Type:
|
section
|
Fixation:
|
Paraformaldehyde
|
Embedding:
|
Agarose
|
Specimen
5F:
postnatal adult; Sox8tm1Weg/Sox8 +
(more )
Specimen
5F:
(close )
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
Mutant Allele(s):
|
Sox8tm1Weg/Sox8+
|
Age:
|
postnatal adult
|
Sex:
|
Not Specified
|
Type:
|
section
|
Fixation:
|
Paraformaldehyde
|
Embedding:
|
Agarose
|
Specimen
5G:
(close )
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
Mutant Allele(s):
|
Sox8tm1Weg/Sox8tm1Weg
|
Age:
|
postnatal adult
|
Sex:
|
Not Specified
|
Type:
|
section
|
Fixation:
|
Paraformaldehyde
|
Embedding:
|
Agarose
|
Structure |
Level |
Pattern |
Image |
Note |
TS28: skeletal muscle |
Present |
Regionally restricted |
5G
|
Authors report expression in twice as many cells in homozygote as heterozygote. Selective expression in endplates of neuromuscular junctions.
|
|