About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:191972 Huang S, et al., Wls is expressed in the epidermis and regulates embryonic hair follicle induction in mice. PLoS One. 2012;7(9):e45904
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6403100
Gene symbol: Wls
Gene name: wntless WNT ligand secretion mediator
Antibody: anti-Wls
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 1A: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: epidermis Present 1A surface ectoderm
TS21: dermis Present 1A mesenchyme underlying the surface ectoderm
Specimen 1B: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: epidermis Present 1B
TS22: hair epidermal placode Present 1B
Specimen 1C: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: epidermis Present 1C
TS23: hair epidermal placode Present 1C
Specimen 1D: postnatal (more )
Note: anagen I stage
Structure Level Pattern Image Note
TS28: hair follicle bulge Strong 1D
TS28: hair follicle dermal papilla Present 1D
TS28: hair germ Present Regionally restricted 1D Expressed in the second hair germ, which connects the bulge and dermal papilla.
Specimen 1E: postnatal (more )
Note: anagen V stage
Structure Level Pattern Image Note
TS28: hair follicle matrix region Strong 1E keratinocyte matrix
TS28: hair shaft Strong 1E pre-hair shaft region
TS28: hair follicle dermal papilla Weak 1E
TS28: hair root sheath Absent 1E
Specimen 1F: postnatal (more )
Note: catagen I stage
Structure Level Pattern Image Note
TS28: hair inner root sheath Present 1F
TS28: hair outer root sheath Present 1F
TS28: hair shaft Present 1F
TS28: hair follicle dermal papilla Weak 1F
Specimen 1G: postnatal (more )
Note: catagen VI stage
Structure Level Pattern Image Note
TS28: hair follicle dermal papilla Present 1G Increased expression.
TS28: hair inner root sheath Present 1G Decreased expression.
TS28: hair outer root sheath Present 1G Decreased expression.
TS28: hair shaft Present 1G Decreased expression.
TS28: hair bulb Weak Regionally restricted 1G Expression was almost absent in the epithelial strand.
Specimen 1H: postnatal (more )
Note: catagen VII stage
Structure Level Pattern Image Note
TS28: hair follicle dermal papilla Present 1H
TS28: hair bulb Present Regionally restricted 1H Expressed in the lower part of hair follicles.
Specimen 1I: postnatal (more )
Note: telogen stage
Structure Level Pattern Image Note
TS28: hair follicle bulge Present 1I
TS28: hair follicle dermal papilla Present 1I relatively weak
Specimen 2H: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: epidermis Present 2H
Specimen 2I: embryonic day 13.5; Wlstm1Xzg/Wlstm1Xzg, Krt14tm1(cre)Wbm/Krt14+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: epidermis Trace 2I Significantly reduced expression compared with the wild-type control.
Specimen 2J: postnatal day 17 (more )
Structure Level Pattern Image Note
TS28: epidermis Present 2J
Specimen 2K: postnatal day 17; Wlstm1Xzg/Wlstm1Xzg, Krt14tm1(cre)Wbm/Krt14+ (more )
Note: Conditional mutant. hairless patches
Structure Level Pattern Image Note
TS28: epidermis Trace 2K Significantly reduced expression compared with the wild-type control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory