Dab1 Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:257927 Fairchild CL, et al., RBX2 maintains final retinal cell position in a DAB1-dependent and -independent fashion. Development. 2018 Feb 2;145(3):dev155283
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:6430438
Gene symbol:	Dab1
Gene name:	disabled 1

Antibody:	Anti-Dab1 (HPA052033)
Assay notes:	Two antibodies were described MGI:6430200 and MGI:6430189. The antibody used in this assay was not specified; either of these antibodies could have been used.

Results

3D ©

3D' ©

Specimen 3D: postnatal day 15 (more

)
Note: The genetic background of the conditional control specimen was not specified.

Structure	Level	Pattern	Image	Note
TS28: retina	Present	Regionally restricted	3D , 3D'	Expression was detected in AII amacrine cells.

3E ©

3E' ©

Specimen 3E: postnatal day 15; Rnf7^{tm1c(EUCOMM)Wtsi}/Rnf7^{tm1c(EUCOMM)Wtsi}, Tg(Nes-cre)1Kln/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS28: retina	Present	Regionally restricted	3E , 3E'	In the conditional mutant, expression accumulated in the AII-amacrine cells and, most prominently, in the distal dendrites of these cells.

3F ©

3F' ©

Specimen 3F: postnatal day 15 (more

)
Note: The genetic background of the conditional control specimen was not specified.

Structure	Level	Pattern	Image	Note
TS28: lens epithelium	Present		3F , 3F'
TS28: lens fiber	Ambiguous		3F' , 3F

3G ©

3G' ©

Specimen 3G: postnatal day 15; Rnf7^{tm1c(EUCOMM)Wtsi}/Rnf7^{tm1c(EUCOMM)Wtsi}, Tg(Nes-cre)1Kln/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS28: lens epithelium	Present		3G' , 3G	In the conditional mutant, Dab1 accumulated in the cytoplasm of the lens epithelium.
TS28: lens fiber	Present		3G , 3G'	In the conditional mutant, Dab1 accumulated in the nuclei of the secondary fibers of the lens.

8C ©

8C' ©

Specimen 8C: postnatal day 15 (more

)

Structure	Level	Pattern	Image	Note
TS28: retina	Present	Regionally restricted	8C , 8C'	Expression was detected mainly in AII-amacrine cells.

8D ©

8D' ©

Specimen 8D: postnatal day 15; Socs7^{tm1b(EUCOMM)Wtsi}/Socs7^{tm1b(EUCOMM)Wtsi} (more

)

Structure	Level	Pattern	Image	Note
TS28: retina	Present	Regionally restricted	8D , 8D'	Expression accumulated in AII-amacrine cells in the knockout mutant.

S3A ©

S3A' ©

Specimen S3A: postnatal day 20 (more

)
Note: The genetic background of the conditional control specimen was not specified.

Structure	Level	Pattern	Image	Note
TS28: retina	Present		S3A , S3A'

S3B ©

S3B' ©

Specimen S3B: postnatal day 20; Rnf7^{tm1c(EUCOMM)Wtsi}/Rnf7^{tm1c(EUCOMM)Wtsi}, Tg(Crx-cre)352Gla/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS28: retina	Present		S3B' , S3B	No Dab1 accumulation was observed in Rbx2cKO-Crx retinas.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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