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Gene Expression Data
Assay Details
Assay
Reference: J:138379 Gu S, et al., Shox2-deficiency leads to dysplasia and ankylosis of the temporomandibular joint in mice. Mech Dev. 2008 Aug;125(8):729-42
Assay type: RNA in situ
MGI Accession ID: MGI:6434470
Gene symbol: Runx2
Gene name: runt related transcription factor 2
Probe: Runx2 probe12
Probe preparation: labelled with digoxigenin RNA
Results
Specimen 6C: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: mandible condylar condensation Present 6C
TS21: Meckel's cartilage Absent 6C
Specimen 6D: embryonic day 13.5; Shox2tm1Ddu/Shox2tm1Ypc, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: mandible condylar condensation Weak 6D Significantly down-regulated expression in condylar condensation.
TS21: Meckel's cartilage Absent 6D
Specimen 7C: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: mandible condylar process Present Regionally restricted 7C Expression in condyle mainly restricted to perichondrial region.
TS23: mandibular fossa Present 7C Expression in glenoid fossa.
TS23: Meckel's cartilage Absent 7C
Specimen 7D: embryonic day 15.5; Shox2tm1Ddu/Shox2tm1Ypc, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS23: mandible condylar process Weak 7D Reduced expression in condyle.
TS23: mandibular fossa Weak 7D Reduced expression in glenoid fossa.
TS23: Meckel's cartilage Absent 7D
Specimen 7I: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: mandibular fossa Strong 7I Strong expression in glenoid fossa primordium.
Specimen E14.5 mutant not shown: embryonic day 14.5; Shox2tm1Ddu/Shox2tm1Ypc, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: mandibular fossa Trace
Specimen 7J: embryonic day 15.5; Shox2tm1Ddu/Shox2tm1Ypc, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS23: mandibular fossa Weak 7J Reduced level of expression in glenoid fossa.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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06/12/2024
MGI 6.13 		The Jackson Laboratory