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Gene Expression Data
Assay Details
Assay
Reference: J:111788 Kiyozumi D, et al., Breakdown of the reciprocal stabilization of QBRICK/Frem1, Fras1, and Frem2 at the basement membrane provokes Fraser syndrome-like defects. Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):11981-6
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6454312
Gene symbol: Frem2
Gene name: Fras1 related extracellular matrix protein 2
Antibody: anti-Frem2
Detection system: Alexa Fluor 488
Results
Specimen 1B: embryonic day 17.5 (more )
Note: Double labeled: green - Frem2; red - Lamc1 (assay MGI:6454314).
Structure Level Pattern Image Note
TS25: back skin Present Regionally restricted 1B Expression in epidermal basement membrane, colocalizing with that of Lamc1.
Specimen 2B my/+ left: embryonic day 13.5; Frem2my/Frem2+ (more )
Structure Level Pattern Image Note
TS21: back skin Present 2B my/+ left
Specimen 2B my/my left: embryonic day 13.5; Frem2my/Frem2my (more )
Structure Level Pattern Image Note
TS21: back skin Trace 2B my/my left Scarce expression in my/my, reduced compared with my/+.
Specimen 2C my/+ left: embryonic day 17.5; Frem2my/Frem2+ (more )
Structure Level Pattern Image Note
TS25: back skin Present 2C my/+ left
Specimen 2C my/my left: embryonic day 17.5; Frem2my/Frem2my (more )
Structure Level Pattern Image Note
TS25: back skin Trace 2C my/my left Scarce expression in my/my, reduced compared with my/+.
Specimen 2D my/+ left: postnatal newborn; Frem2my/Frem2+ (more )
Structure Level Pattern Image Note
TS27: back skin Present 2D my/+ left
Specimen 2D my/my left: postnatal newborn; Frem2my/Frem2my (more )
Structure Level Pattern Image Note
TS27: back skin Trace 2D my/my left Scarce expression in my/my, reduced compared with my/+.
Specimen 3A eb/+ left: embryonic day 14.5; Grip1eb/Grip1+ (more )
Structure Level Pattern Image Note
TS22: back skin Present 3A eb/+ left
Specimen 3A eb/eb left: embryonic day 14.5; Grip1eb/Grip1eb (more )
Structure Level Pattern Image Note
TS22: back skin Weak 3A eb/eb left Expression was reduced in eb/eb compared with eb/+ embryos.
Specimen 3B eb/+ left: postnatal newborn; Grip1eb/Grip1+ (more )
Structure Level Pattern Image Note
TS27: back skin Present 3B eb/+ left
Specimen 3B eb/eb left: postnatal newborn; Grip1eb/Grip1eb (more )
Structure Level Pattern Image Note
TS27: back skin Trace 3B eb/eb left Reduction in expression more prominent in newborn mice.
Specimen 5H +/- left: embryonic day 14.5; Frem1tm1Ksek/Frem1+ (more )
Structure Level Pattern Image Note
TS22: back skin Present 5H +/- left
Specimen 5H -/- left: embryonic day 14.5; Frem1tm1Ksek/Frem1tm1Ksek (more )
Structure Level Pattern Image Note
TS22: back skin Weak 5H -/- left Expression reduced in comparison to heterozygotes.
Specimen 5I +/- left: postnatal newborn; Frem1tm1Ksek/Frem1+ (more )
Structure Level Pattern Image Note
TS27: back skin Present 5I +/- left
Specimen 5I -/- left: postnatal newborn; Frem1tm1Ksek/Frem1tm1Ksek (more )
Structure Level Pattern Image Note
TS27: back skin Weak 5I -/- left Expression reduced in comparison to heterozygotes.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/10/2024
MGI 6.24 		The Jackson Laboratory