Flg Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:228856 DiTommaso T, et al., Keratin 76 is required for tight junction function and maintenance of the skin barrier. PLoS Genet. 2014 Oct;10(10):e1004706
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:6456585
Gene symbol:	Flg
Gene name:	filaggrin

Antibody:

Results

1K FLG ©

Specimen 1K FLG: postnatal adult (more

)
Note: Double labeled: red - Flg; blue - DAPI.

Structure	Level	Pattern	Image	Note
TS28: metapodial pad epidermis	Present	Regionally restricted	1K FLG	Expression around the granular layer.

3D +/+ ©

Specimen 3D +/+: postnatal adult (more

)
Note: Triple labeled: green - Flg; red - Krt14 (assay MGI:6456584); blue - DAPI.

Structure	Level	Pattern	Image	Note
TS28: epidermis granular layer	Present		3D +/+

3D (Early) ©

Specimen 3D (Early): postnatal adult; Krt76^{tm1a(KOMP)Wtsi}/Krt76^{tm1a(KOMP)Wtsi} (more

)
Note: Triple labeled: green - Flg; red - Krt14 (assay MGI:6456584); blue - DAPI.

Structure	Level	Pattern	Image	Note
TS28: epidermis granular layer	Present		3D (Early)	Authors report normal expression in "early" phenotype mice.

3D (Late) ©

Specimen 3D (Late): postnatal adult; Krt76^{tm1a(KOMP)Wtsi}/Krt76^{tm1a(KOMP)Wtsi} (more

)
Note: Triple labeled: green - Flg; red - Krt14 (assay MGI:6456584); blue - DAPI.

Structure	Level	Pattern	Image	Note
TS28: back skin	Strong	Regionally restricted	3D (Late)	Expression expanded in "late" phenotype mice.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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