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Gene Expression Data
Assay Details
Assay
Reference: J:173123 Mahoney Rogers AA, et al., Sprouty1 and Sprouty2 limit both the size of the otic placode and hindbrain Wnt8a by antagonizing FGF signaling. Dev Biol. 2011 May 1;353(1):94-104
Assay type: RNA in situ
MGI Accession ID: MGI:6471917
Gene symbol: Dlx5
Gene name: distal-less homeobox 5
Probe: Dlx5 probe27
Probe preparation: labelled with digoxigenin RNA
Results
Specimen 1C: embryonic day 8.0; Spry1tm1.1Jdli/Spry1+, Spry2tm1.1Mrt/Spry2+ (more )
Note: 6 somite stage.
Structure Level Pattern Image Note
TS12: otic pre-placode Present 1C
Specimen 1D: embryonic day 8.0; Spry1tm1.1Jdli/Spry1tm1.1Jdli, Spry2tm1.1Mrt/Spry2tm1.1Mrt (more )
Note: 6 somite stage.
Structure Level Pattern Image Note
TS12: otic pre-placode Present 1D No signficant difference in size or intensity of expression domain compared to control.
Specimen 1I: embryonic day 8.5; Spry1tm1.1Jdli/Spry1+, Spry2tm1.1Mrt/Spry2+ (more )
Note: 9 somite stage.
Structure Level Pattern Image Note
TS13: otic placode Present 1I
Specimen 1J: embryonic day 8.5; Spry1tm1.1Jdli/Spry1tm1.1Jdli, Spry2tm1.1Mrt/Spry2tm1.1Mrt (more )
Note: 9 somite stage.
Structure Level Pattern Image Note
TS13: otic placode Present Regionally restricted 1J
Specimen 6A: embryonic day 9.0; Spry1tm1.1Jdli/Spry1+, Spry2tm1.1Mrt/Spry2+ (more )
Note: 15-16 somite stage.
Structure Level Pattern Image Note
TS14: otic placode Present 6A
Specimen not shown: embryonic day 9.0; Fgf10tm1Wss/Fgf10+, Spry1tm1.1Jdli/Spry1+, Spry2tm1.1Mrt/Spry2+ (more )
Note: 14-18 somite stage.
Structure Level Pattern Image Note
TS14: otic placode Present Expression indistinguishable from control.
Specimen 6B: embryonic day 9.0; Spry1tm1.1Jdli/Spry1tm1.1Jdli, Spry2tm1.1Mrt/Spry2tm1.1Mrt (more )
Note: 14-15 somite stage.
Structure Level Pattern Image Note
TS14: otic placode Present Regionally restricted 6B Expression domain enlarged.
Specimen 6C: embryonic day 9.0; Fgf10tm1Wss/Fgf10+, Spry1tm1.1Jdli/Spry1tm1.1Jdli, Spry2tm1.1Mrt/Spry2tm1.1Mrt (more )
Note: 15-16 somite stage.
Structure Level Pattern Image Note
TS14: otic placode Present 6C Normal sized otic expression domain in 3/5 of embryos.
Specimen 6D: embryonic day 9.0; Fgf10tm1Wss/Fgf10+, Spry1tm1.1Jdli/Spry1tm1.1Jdli, Spry2tm1.1Mrt/Spry2tm1.1Mrt (more )
Note: 14-15 somite stage.
Structure Level Pattern Image Note
TS14: otic placode Present Regionally restricted 6D In 2/5 of embryos, expression domain was an intermediate size.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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06/12/2024
MGI 6.13 		The Jackson Laboratory