Sox10 RNA in situ Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:179369 Zhang Y, et al., Phactr4 regulates directional migration of enteric neural crest through PP1, integrin signaling, and cofilin activity. Genes Dev. 2012 Jan 1;26(1):69-81
Assay type:	RNA in situ
MGI Accession ID:	MGI:6506181
Gene symbol:	Sox10
Gene name:	SRY (sex determining region Y)-box 10

Probe:	Sox10 probe26
Probe preparation:	labelled with digoxigenin RNA
Visualized with:	Alkaline phosphatase

Results

S1C (left) ©

Specimen S1C (left): embryonic day 11.5 (more

)

Structure	Level	Pattern	Image	Note
TS19: stomach	Strong		S1C (left)
TS19: intestine	Strong	Regionally restricted	S1C (left)	Strong expression in rostral intestine.

S1C (right) ©

Specimen S1C (right): embryonic day 11.5; E2f1^tm1Meg/E2f1^tm1Meg, Phactr4^humdy/Phactr4^humdy (more

)

Structure	Level	Pattern	Image	Note
TS19: stomach	Weak		S1C (right)
TS19: intestine	Weak	Regionally restricted	S1C (right)	Expression reduced in rostral intestine.

S1D ©

Specimen S1D: embryonic day 11.5; Phactr4^humdy/Phactr4^humdy (more

)

Structure	Level	Pattern	Image	Note
TS19: stomach	Weak		S1D
TS19: intestine	Weak	Regionally restricted	S1D	Expression reduced in rostral intestine.

S2C ©

Specimen S2C: embryonic day 9.5 (more

)

Structure	Level	Pattern	Image	Note
TS15: migrating neural crest	Present		S2C

S2D ©

Specimen S2D: embryonic day 9.5; Phactr4^humdy/Phactr4^humdy (more

)

Structure	Level	Pattern	Image	Note
TS15: migrating neural crest	Present		S2D	Neural crest cell specification appeared normal.

S3D ©

Specimen S3D: embryonic day 12.5 (more

)

Structure	Level	Pattern	Image	Note
TS20: gut	Present	Regionally restricted	S3D
TS20: migrating neural crest	Present	Regionally restricted	S3D

S3E ©

Specimen S3E: embryonic day 12.5; Phactr4^humdy/Phactr4^humdy (more

)

Structure	Level	Pattern	Image	Note
TS20: gut	Present	Regionally restricted	S3E	Enteric neural crest cell (ENCC) migration is disrupted.
TS20: migrating neural crest	Present	Regionally restricted	S3E	Enteric neural crest cell (ENCC) migration is disrupted.

S3F ©

Specimen S3F: embryonic day 13.5 (more

)

Structure	Level	Pattern	Image	Note
TS21: gut	Present	Regionally restricted	S3F
TS21: migrating neural crest	Present	Regionally restricted	S3F

S3G ©

Specimen S3G: embryonic day 13.5; Phactr4^humdy/Phactr4^humdy (more

)

Structure	Level	Pattern	Image	Note
TS21: gut	Present	Regionally restricted	S3G	Enteric neural crest cell (ENCC) migration is disrupted.
TS21: migrating neural crest	Present	Regionally restricted	S3G	Enteric neural crest cell (ENCC) migration is disrupted.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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