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Gene Expression Data
Assay Details
Assay
Reference: J:295945 Kawamura N, et al., Rab7-Mediated Endocytosis Establishes Patterning of Wnt Activity through Inactivation of Dkk Antagonism. Cell Rep. 2020 Jun 9;31(10):107733
Assay type: RNA in situ
MGI Accession ID: MGI:6711844
Gene symbol: T
Gene name: brachyury, T-box transcription factor T
Probe: Brachyury probe29
Probe preparation: Antisense RNA
Results
Specimen 1A WT: embryonic day 7.5 (more )
Structure Level Pattern Image Note
TS11: embryo mesoderm Present 1A upper left
Specimen 1A -/-: embryonic day 7.5; Rab7tm1.2Ywd/Rab7tm1.2Ywd (more )
Structure Level Pattern Image Note
TS11: embryo mesoderm Present Regionally restricted 1A lower left Expressed in the nascent mesoderm, which failed to migrate and the primitive streak did not elongate.
Specimen 3B flox/-: embryonic day 7.5; Rab7tm1.1Ywd/Rab7tm1.2Ywd (more )
Structure Level Pattern Image Note
TS11: embryo mesoderm Present 3B-1
Specimen 3B Ttr-cKO: embryonic day 7.5; Rab7tm1.1Ywd/Rab7tm1.2Ywd, Tg(Ttr-cre)1Hadj/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS11: embryo mesoderm Present Regionally restricted 3B-2 Expression was initiated at the proximal posterior region, but positive cells did not organize into an elongated primitive streak.
Specimen S2B flox/+: embryonic day 7.5; Rab7tm1.1Ywd/Rab7+ (more )
Structure Level Pattern Image Note
TS11: embryo mesoderm Present S2B-1 Similar as in the wild-type.
Specimen S2B flox/-: embryonic day 7.5; Rab7tm1.1Ywd/Rab7tm1.2Ywd (more )
Structure Level Pattern Image Note
TS11: embryo mesoderm Present S2B-2 Similar as in the wild-type.
Specimen S2B flox/+, Sox2cre/+: embryonic day 7.5; Edil3Tg(Sox2-cre)1Amc/Edil3+, Rab7tm1.1Ywd/Rab7+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS11: embryo mesoderm Present S2B-3 Similar as in the wild-type.
Specimen S2B Sox2-cKO: embryonic day 7.5; Edil3Tg(Sox2-cre)1Amc/Edil3+, Rab7tm1.1Ywd/Rab7tm1.2Ywd (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS11: embryo mesoderm Present S2B-4 Similar as in the wild-type.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/09/2024
MGI 6.24 		The Jackson Laboratory