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Gene Expression Data
Assay Details
Assay
Reference: J:286480 Kuroki S, et al., Combined Loss of JMJD1A and JMJD1B Reveals Critical Roles for H3K9 Demethylation in the Maintenance of Embryonic Stem Cells and Early Embryogenesis. Stem Cell Reports. 2018 Apr 10;10(4):1340-1354
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7262884
Gene symbol: Pou5f1
Gene name: POU domain, class 5, transcription factor 1
Antibody: anti-Oct4 antibody (ab19857)
Detection system: Secondary antibody coupled to Alexa Fluor
Results
Specimen 1D 1a+/delta;1b +/delta: embryonic day 6.5; Kdm3atm1.1Jsak/Kdm3a+, Kdm3btm2.1Mtac/Kdm3b+ (more )
Structure Level Pattern Image Note
TS9: embryo Present Regionally restricted 1D top left , 1D bottom left Expression is in the epiblast.
Specimen 1D left 1a delta/delta; 1b delta/delta: embryonic day 6.5; Kdm3atm1.1Jsak/Kdm3atm1.1Jsak, Kdm3btm2.1Mtac/Kdm3btm2.1Mtac (more )
Structure Level Pattern Image Note
TS9: embryo Weak Regionally restricted 1D top middle , 1D bottom middle This mutant had a smaller epiblast compared to controls. In some mutants the epiblast was absent.
Specimen 1D right 1a delta/delta; 1b delta/delta: embryonic day 6.5; Kdm3atm1.1Jsak/Kdm3atm1.1Jsak, Kdm3btm2.1Mtac/Kdm3btm2.1Mtac (more )
Structure Level Pattern Image Note
TS9: embryo Absent 1D bottom right , 1D top right This mutant had no detectable epiblast. In some double mutants there was a small epiblast.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/17/2024
MGI 6.24 		The Jackson Laboratory