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Gene Expression Data
Assay Details
Assay
Reference: J:244087 Stopp S, et al., Deletion of Gas2l3 in mice leads to specific defects in cardiomyocyte cytokinesis during development. Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):8029-8034
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7278835
Gene symbol: Mki67
Gene name: antigen identified by monoclonal antibody Ki 67
Antibody: anti-Ki67
Detection system: Secondary antibody coupled to Alexa Fluor 594
Results
Specimen 3C wildtype: embryonic day 14.5 (more )
Note: Double labeled: red - Mki67; green - Tnnt2 (assay MGI:7278834).
Structure Cell Type Level Pattern Image Note
TS22: heart cardiac muscle cell Present 3C wildtype Expression in cardiomyocytes.
Specimen 3C Gas2l3-/-: embryonic day 14.5; Gas2l3tm1d(EUCOMM)Hmgu/Gas2l3tm1d(EUCOMM)Hmgu (more )
Note: Double labeled: red - Mki67; green - Tnnt2 (assay MGI:7278834).
Structure Cell Type Level Pattern Image Note
TS22: heart cardiac muscle cell Weak 3C Gas2l3-/- Significantly decreased proportion of expressing cells compared with control.
Specimen E16.5 +/+ not shown: embryonic day 16.5 (more )
Structure Cell Type Level Pattern Image Note
TS24: heart cardiac muscle cell Present Expression in cardiomyocytes.
Specimen E16.5 -/- not shown: embryonic day 16.5; Gas2l3tm1d(EUCOMM)Hmgu/Gas2l3tm1d(EUCOMM)Hmgu (more )
Structure Cell Type Level Pattern Image Note
TS24: heart cardiac muscle cell Weak Significantly decreased proportion of expressing cells compared with control.
Specimen E18.5 +/+ not shown: embryonic day 18.5 (more )
Structure Cell Type Level Pattern Image Note
TS26: heart cardiac muscle cell Present Expression in cardiomyocytes.
Specimen E18.5 -/- not shown: embryonic day 18.5; Gas2l3tm1d(EUCOMM)Hmgu/Gas2l3tm1d(EUCOMM)Hmgu (more )
Structure Cell Type Level Pattern Image Note
TS26: heart cardiac muscle cell Weak Significantly decreased proportion of expressing cells compared with control.
Specimen P1 +/+ not shown: postnatal day 1 (more )
Structure Cell Type Level Pattern Image Note
TS27: heart cardiac muscle cell Present Expression in cardiomyocytes.
Specimen P1 -/- not shown: postnatal day 1; Gas2l3tm1d(EUCOMM)Hmgu/Gas2l3tm1d(EUCOMM)Hmgu (more )
Structure Cell Type Level Pattern Image Note
TS27: heart cardiac muscle cell Present Expression in cardiomyocytes.
Specimen P7 +/+ not shown: postnatal day 7 (more )
Structure Cell Type Level Pattern Image Note
TS28: heart cardiac muscle cell Present Expression in cardiomyocytes.
Specimen P7 -/- not shown: postnatal day 7; Gas2l3tm1d(EUCOMM)Hmgu/Gas2l3tm1d(EUCOMM)Hmgu (more )
Structure Cell Type Level Pattern Image Note
TS28: heart cardiac muscle cell Present Expression in cardiomyocytes.
Specimen S6A control: embryonic day 14.5 (more )
Structure Cell Type Level Pattern Image Note
TS22: liver hepatocyte Present S6A control merge , S6A control Ki67
Specimen S6A knockout: embryonic day 14.5; Gas2l3tm1d(EUCOMM)Hmgu/Gas2l3tm1d(EUCOMM)Hmgu (more )
Structure Cell Type Level Pattern Image Note
TS22: liver hepatocyte Present S6A knockout merge , S6A knockout Ki67 Proliferation of hepatocytes not affected compared with control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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10/09/2024
MGI 6.24 		The Jackson Laboratory