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Gene Expression Data
Assay Details
Assay
Reference: J:260445 Wang C, et al., Centrosomal protein Dzip1l binds Cby, promotes ciliary bud formation, and acts redundantly with Bromi to regulate ciliogenesis in the mouse. Development. 2018 Mar 15;145(6):dev164236
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7281357
Gene symbol: Nkx2-2
Gene name: NK2 homeobox 2
Antibody: anti-Nkx2-2
Results
Specimen 1D WT: embryonic day 10.5 (more )
Note: Double labeled: red - Nkx2-2; green - Pax6 (assay MGI:7281377).
Structure Level Pattern Image Note
TS17: neural tube lateral wall Present Regionally restricted 1D WT Nkx2.2/Pax6 Expression is in p3 interneuron progenitors.
Specimen 1D Dzip1l-/-: embryonic day 10.5; Dzip1ltm1Blnw/Dzip1ltm1Blnw (more )
Note: Double labeled: red - Nkx2-2; green - Pax6 (assay MGI:7281377).
Structure Level Pattern Image Note
TS17: neural tube lateral wall Present Regionally restricted 1D Dzip1-/- Nkx2.2/Pax6 Expression in this mutant is the same as in wild-type.
Specimen 6B WT: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: neural tube lateral wall Present Regionally restricted 6B WT Nkx2.2 Expression is in p3 interneuron progenitors.
Specimen 6B Dzip1l-/-: embryonic day 10.5; Dzip1ltm1Blnw/Dzip1ltm1Blnw (more )
Structure Level Pattern Image Note
TS17: neural tube lateral wall Present Regionally restricted 6B Dzip1l-/- Nkx2.2 Expression in this mutant is the same as in wild-type.
Specimen 6B Bromi-/-: embryonic day 10.5; Tbc1d32tm1Blnw/Tbc1d32tm1Blnw (more )
Structure Level Pattern Image Note
TS17: neural tube lateral wall Present Regionally restricted 6B Bromi-/- Nkx2.2 The floor plate is missing in this mutant and the p3 interneuron progenitors were shifted to the most ventral region of the neural tube.
Specimen 6B Cby-/-: embryonic day 10.5; Cby1tm1Ktkm/Cby1tm1Ktkm (more )
Structure Level Pattern Image Note
TS17: neural tube lateral wall Present Regionally restricted 6B Cby-/- Nkx2.2 Expression in this mutant is the same as in wild-type.
Specimen 6B Dzip1l-/-;Bromi-/-: embryonic day 10.5; Dzip1ltm1Blnw/Dzip1ltm1Blnw, Tbc1d32tm1Blnw/Tbc1d32tm1Blnw (more )
Structure Level Pattern Image Note
TS17: neural tube lateral wall Absent 6B Dzip1l-/-;Bromi-/- Nkx2.2
Specimen 6B Dzip1l-/-;Cby-/-: embryonic day 10.5; Cby1tm1Ktkm/Cby1tm1Ktkm, Dzip1ltm1Blnw/Dzip1ltm1Blnw (more )
Structure Level Pattern Image Note
TS17: neural tube lateral wall Present 6B Dzip1l-/-;Cby-/- Nkx2.2 The floor plate is missing in this mutant and the p3 interneuron progenitors were shifted to the most ventral region of the neural tube.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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06/12/2024
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