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Gene Expression Data
Assay Details
Assay
Reference: J:171508 Ikegami D, et al., Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways. Development. 2011 Apr;138(8):1507-19
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7286477
Gene symbol: Col1a1
Gene name: collagen, type I, alpha 1
Antibody: anti-Col1 (ab34710)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Assay notes: The antibody specificity was not detailed and may recognize a related gene; Col1a2 has also been annotated.
Results
Specimen 3A Sox9flox/+: embryonic day 13.5; Sox9tm2Crm/Sox9+ (more )
Note: Proximal humerus.
Structure Level Pattern Image Note
TS21: humerus cartilage condensation Present Regionally restricted 3A anti-type I collagen Sox9flox/+ Expression was in the bone collar.
Specimen 3A 11Prom-Cre; Sox9flox/flox: embryonic day 13.5; Sox9tm2Crm/Sox9tm2Crm, Tg(Col11a2-cre)2Ntsu/0 (more )
Note: Conditional mutant. Proximal humerus.
Structure Level Pattern Image Note
TS21: humerus cartilage condensation Present Regionally restricted 3A anti-type I collagen 11Prom-Cre; Sox9flox/flox Expression was increased in the bone collar in the conditional mutant.
Specimen 3D Sox9flox/+: embryonic day 14.5; Sox9tm2Crm/Sox9+ (more )
Structure Cell Type Level Pattern Image Note
TS22: humerus cartilage condensation chondrocyte Absent 3D anti-type I collagen Sox9flox/+
Specimen 3D 11Prom-Cre; Sox9flox/flox: embryonic day 14.5; Sox9tm2Crm/Sox9tm2Crm, Tg(Col11a2-cre)2Ntsu/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS22: humerus cartilage condensation chondrocyte Present Regionally restricted 3D anti-type I collagen 11Prom-Cre; Sox9flox/flox Ectopic expression was detected in the chondrocytes in the central region of conditional mutant humeral cartilage.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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06/12/2024
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